Last update May 14, 2024
Compatible
We do not have alternatives for A11HA04; S01XA26 since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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A11HA04; S01XA26 is Riboflavin (Vitamin B2) in ATC Code/s.
Is written in other languages:A11HA04; S01XA26 is also known as
A11HA04; S01XA26 belongs to these groups or families:
Main tradenames from several countries containing A11HA04; S01XA26 in its composition:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 60 | % |
Molecular weight | 376 | daltons |
Protein Binding | 60 | % |
Tmax | 1.5 - 2 | hours |
T½ | 3.9 | hours |
Theoretical Dose | 0.00006 | mg/Kg/d |
Relative Dose | 0.35 | % |
Ped.Relat.Dose | 0.4 | % |
Write us at elactancia.org@gmail.com
e-lactancia is a resource recommended by IHAN of Spain
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
Riboflavin is a water-soluble vitamin that is essential for the utilization of energy from food. It is found in milk, meat, eggs, nuts, and vegetables (MedlinePlus 2020). It is used to correct vitamin B2 deficiency or aryboflavinosis. At high doses it is used to prevent migraine attacks. Riboflavin is also a food coloring (E101).
The riboflavin concentration in human milk depends on dietary intake of this vitamin being higher in well-nourished women (NIH prof 2022, Allen 2012, Sakurai 2005); it is also higher in transitional and mature milk than in colostrum. (Ren 2015)
The recommended daily allowance (RDA) of vitamin B2 for lactating women is 1.6 mg (NIH 2022, Sauberan 2019, Ares 2015, Hall 2010). Supplementation is not necessary in healthy, well-nourished women. (Thomas 1980, Nail 1980)
Up to 50% of the riboflavin in donated milk is destroyed in bottles or nasogastric tubes exposed to daylight or phototherapy, which may contribute to the high incidence of riboflavin deficiency in premature infants receiving donated breast milk without vitamin supplements. (Bates 1985)
Given its rapid elimination from the body when consumed in excess, no studies have reported significant adverse effects in humans from excessive consumption of riboflavin through food or supplements (Lee 2023). No upper limit (UL) of daily tolerability or toxic dose of this vitamin has been established in humans (Sauberan 2019, EFSA 2006). It is recognized as generally safe by the FDA. (FDA 2023)
With an adequate diet it is not necessary to take supplements of this vitamin.
Various medical societies and expert authors consider the use of this medication safe during breastfeeding. (Hale, Briggs 2015)
Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs: compatible with Breastfeeding. (WHO 2002). American Academy of Pediatrics: medication usually compatible with breastfeeding.(AAP 2001)