Last update May 19, 2021

4′-tert-Butyl-4-[4-(diphenylmethoxy)piperidino]butyrophenone

Compatible

Safe substance and/or breastfeeding is the best option.

Second generation anti-histaminic and piperidine drug with a slightly sedative effect.
It is indicated in the symptomatic treatment of allergic rhinitis and pruritic skin disorders.
Oral administration once daily.

It is excreted in breast milk in clinically insignificant amounts and no problems have been observed in infants whose mothers have taken it . Plasma levels in these infants were very low (Saito 2020).

Its high percentage of plasma protein binding and very high volume of distribution (Cuvillo 2006) explain the negligible passage into milk observed.

Second generation anti-histaminic medicines are considered to be safe while breastfeeding (So 2010, Leimgruber 2007, Solhaug 2004).

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

4′-tert-Butyl-4-[4-(diphenylmethoxy)piperidino]butyrophenone is Ebastine in Chemical name.

Is written in other languages:

Group

4′-tert-Butyl-4-[4-(diphenylmethoxy)piperidino]butyrophenone belongs to this group or family:

Tradenames

Main tradenames from several countries containing 4′-tert-Butyl-4-[4-(diphenylmethoxy)piperidino]butyrophenone in its composition:

List of 9 tradenames

Pharmacokinetics

Variable Value Unit
Molecular weight 469 daltons
Protein Binding > 95 %
VD > 100 l/Kg
pKa 16.45 -
Tmax 2.6 - 4 hours
T½ 13.8 - 19 hours
M/P ratio 4.5 -
Theoretical Dose 0.001 mg/Kg/d
Relative Dose 0.57 %

References

  1. Saito J, Yakuwa N, Sandaiji N, Yagishita S, Kawasaki H, Suzuki T, Ozawa K, Kamura S, Yamatani A, Wada S, Sago H, Murashima A. Ebastine during pregnancy and lactation in a patient with chronic urticaria: ebastine and carebastine levels in maternal serum, cord blood, breast milk and the infant's serum. J Eur Acad Dermatol Venereol. 2020 Sep;34(9):e496-e497. Abstract
  2. Teva. Ebastine. Drug Summary. 2020 Full text (in our servers)
  3. AEMPS. Ebastina. Ficha técnica. 2017 Full text (in our servers)
  4. So M, Bozzo P, Inoue M, Einarson A. Safety of antihistamines during pregnancy and lactation. Can Fam Physician. 2010 May;56(5):427-9. Abstract Full text (link to original source) Full text (in our servers)
  5. Leimgruber A. [Treatment of asthma and rhinitis during pregnancy and breast feeding]. Rev Med Suisse. 2007 Abstract
  6. del Cuvillo A, Mullol J, Bartra J, Dávila I, Jáuregui I, Montoro J, Sastre J, Valero AL. Comparative pharmacology of the H1 antihistamines. J Investig Allergol Clin Immunol. 2006;16 Suppl 1:3-12. Review. No abstract available. Abstract Full text (link to original source) Full text (in our servers)
  7. Solhaug V, Roland PD. Bruk av antihistaminer under graviditet og amming \ [Use of antihistaminics during pregnancy and breast feeding]. Tidsskr Nor Laegeforen. 2004 Abstract Full text (link to original source) Full text (in our servers)
  8. Yamaguchi T, Hashizume T, Matsuda M, Sakashita M, Fujii T, Sekine Y, Nakashima M, Uematsu T. Pharmacokinetics of the H1-receptor antagonist ebastine and its active metabolite carebastine in healthy subjects. Arzneimittelforschung. 1994 Jan;44(1):59-64. Abstract

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