Last update Sept. 14, 2022

3-(4,5-Diphenyloxazol-2-yl)propionic acid

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID), derived from propionic acid, used to treat osteoarthritis and rheumatoid arthritis. Oral administration once daily.

Since the last update we have not found published data on its excretion in breastmilk.

Its pharmacokinetic data (very high percentage of protein binding and wide volume of distribution) make it highly unlikely that significant quantities will pass into breast milk.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.


  • Diclofenac (Safe substance and/or breastfeeding is the best option.)
  • Ibuprofen (Safe substance and/or breastfeeding is the best option.)
  • Indomethacin; Indometacin (Safe substance and/or breastfeeding is the best option.)
  • Ketorolac Trometamol (Safe substance and/or breastfeeding is the best option.)
  • Piroxicam (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

3-(4,5-Diphenyloxazol-2-yl)propionic acid is Oxaprozin in Chemical name.

Is written in other languages:


3-(4,5-Diphenyloxazol-2-yl)propionic acid belongs to this group or family:


Main tradenames from several countries containing 3-(4,5-Diphenyloxazol-2-yl)propionic acid in its composition:


Variable Value Unit
Oral Bioavail. 95 %
Molecular weight 293 daltons
Protein Binding 99.5 %
VD 0.2 - 0.3 l/Kg
pKa 4.95 -
Tmax 2 - 4 hours
50 - 55 hours


  1. Pfizer. Oxaprozin. Drug Summary. 2007 Full text (in our servers)

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