Last update Aug. 12, 2019

1-Benzhydryl-4-cinnamylpiperazine; (E)-1-(Diphenylmethyl)-4-(3-phenylprop-2-enyl)piperazine

Low Risk

Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

A calcium channel blocker drug and an antihistamine piperazine derivative which has a sedative effect. Chemical structure and effects similar to Flunarizine.
Used to treat nausea and vertigo of Meniere's Disease, and symptoms of Traveler´s Sickness.
It has been withdrawn from the market in several countries because of Parkinson-like symptoms (Teive 2004, Martí 1985).

At latest update relevant published data were not found on excretion into breast milk.

Its high binding capacity to plasma proteins makes it unlikely excretion into breastmilk.

It should be wise on the long-term, the use of a known safer alternative until more data is available on this drug, mostly for children in the neonatal period or in case of prematurity that may be affected by an increased gut permeability. Occasional use to prevent motion sickness may be compatible with breastfeeding.

See below the information of this related product:

  • Flunarizine Hydrochloride ( Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.)


  • Betahistine (Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Diphenhydramine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Ginkgo (Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Nimodipine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

1-Benzhydryl-4-cinnamylpiperazine; (E)-1-(Diphenylmethyl)-4-(3-phenylprop-2-enyl)piperazine is Cinnarizine in Chemical name.

Is written in other languages:


1-Benzhydryl-4-cinnamylpiperazine; (E)-1-(Diphenylmethyl)-4-(3-phenylprop-2-enyl)piperazine belongs to this group or family:


Main tradenames from several countries containing 1-Benzhydryl-4-cinnamylpiperazine; (E)-1-(Diphenylmethyl)-4-(3-phenylprop-2-enyl)piperazine in its composition:


Variable Value Unit
Molecular weight 369 daltons
Protein Binding 91 %
pKa 8.4 -
Tmax 1 - 3 hours
3 - 24 hours


  1. Janssen. Cinarizina (Stugeron forte). Ficha técnica 2017 Full text (in our servers)
  2. Teive HA, Troiano AR, Germiniani FM, Werneck LC. Flunarizine and cinnarizine-induced parkinsonism: a historical and clinical analysis. Parkinsonism Relat Disord. 2004 Abstract
  3. Castañeda-Hernández G, Vargas-Alvarado Y, Aguirre F, Flores-Murrieta FJ. Pharmacokinetics of cinnarizine after single and multiple dosing in healthy volunteers. Arzneimittelforschung. 1993 May;43(5):539-42. Abstract
  4. Paton DM, Webster DR. Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines). Clin Pharmacokinet. 1985 Nov-Dec;10(6):477-97. Review. Abstract
  5. Martí Massó JF, Carrera N, de la Puente E. [Parkinsonism possibly caused by cinnarizine]. Med Clin (Barc). 1985 Abstract

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