Last update Jan. 21, 2021
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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1,3,6,7,8,9-Hexahydro-5-phenyl-2H-[1]benzothieno[2,3-e]-1,4-diazepin-2-one is Bentazepam in Chemical name.
Is written in other languages:1,3,6,7,8,9-Hexahydro-5-phenyl-2H-[1]benzothieno[2,3-e]-1,4-diazepin-2-one belongs to this group or family:
Main tradenames from several countries containing 1,3,6,7,8,9-Hexahydro-5-phenyl-2H-[1]benzothieno[2,3-e]-1,4-diazepin-2-one in its composition:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 86 | % |
Molecular weight | 296 | daltons |
VD | 0.8 | l/Kg |
pKa | 10.36 | - |
Tmax | 0.7 - 1.5 | hours |
T½ | 3 - 4.5 | hours |
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America
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Short-acting benzodiazepine with anxiolytic effect.
Indicated in the control of anxiety.
Oral administration once or three times a day.
Since the last update we have not found any published data on its excretion in breast milk.
It has very few bibliographical references and is marketed in few countries.
Liver toxicity among treated patients has been described (Andrade 2006 y 2000).
The occasional use and low doses of benzodiazepines are compatible with breastfeeding (Kelly 2012, Rubin 2004, Iqbal 2002, Hägg 2000, McElhatton 1994, Lee 1993, Kanto 1982).
It is advisable to choose a short-acting benzodiazepine and minimal effective dose as possible (Rowe 2013), especially in the neonatal period and in case of prematurity because they can accumulate in the infant during chronic use (Sachs 2013).
It is advisable to monitor drowsiness and adequate feeding of the infant.
It is not recommended to share a bed (co-sleeping, bed-sharing) with the baby if this drug is being taken, due to increased risk of asphyxia or sudden infant death (UNICEF 2018, 2017, 2014 and 2013, Landa 2012, ABM 2008, UNICEF 2006).