Last update: Jan. 15, 2019
Minimal risk for breastfeeding and infant.
Urea is the product of degradation of proteins in humans and mammals in general.
It is found naturally in the body, including blood, bile and breastmilk. It is eliminated through urine and sweat.
Its concentration is 10mg/dL in colostrum and 30 mg/dL in mature milk (Lawrence 2016 p 767).
It diffuses passively into breastmilk from blood plasma (Lawrence 2016 p 368).
In medicine it is used in the form of dermatological creams as a moisturizer and, at high concentrations, as a keratolytic.
Since the last update we have not found published data on its excretion in breastmilk.
The small dose and low plasma absorption of most topical dermatological preparations make transfer of significant amounts into breastmilk very unlikely.
Expert authors do not consider it incompatible with breastfeeding (Hale 2017 p 966, Briggs 2017) provided, according to some, it is not applied over large areas of the skin or in occlusive dressings that could increase its absorption (Schaefer 20007, p 766).
We do not have alternatives for Urea since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.
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