Last update: June 17, 2017

Trientine Dihydrochloride

Low Risk for breastfeeding

Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

Copper chelator used in the treatment of Wilson's disease.

It is excreted in breast milk in clinically insignificant amounts (undetectable levels: Izumi 2012).

Copper and zinc levels in breastmilk of mothers treated with penicillamine, trientine or zinc are normal (Izumi 2012).

Oral bioavailability, which is very low during periods of fasting, is practically non-existent in the presence of food, especially milk, so it would be very difficult to pass into the infant plasma from the ingested breast milk (PDR 2016).


Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Trientine Dihydrochloride is also known as

Trientine Dihydrochloride in other languages or writings:


Trientine Dihydrochloride belongs to this group or family:


Main tradenames from several countries containing Trientine Dihydrochloride in its composition:


Variable Value Unit
Oral Bioavail. 6 - 18 %
Molecular weight 219 daltons
Tmax 2 hours
T1/2 2 - 4 hours


  1. PDR. Trientine hydrochloride. Drug Summary. 2016 Full text (link to original source) Full text (in our servers)
  2. Izumi Y. Can mothers with Wilson's disease give her breast milk to their infant? Teikyo Med J. 2012;35:17-24. 2012 Full text (link to original source) Full text (in our servers)

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