Last update: Aug. 7, 2019

Sumatriptan

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Selective agonist for the vascular receptor of 5-hydroxytryptamine-1 (5-HT1, serotonin) with vasoconstrictor action at the intracranial level.
Indicated in acute migraine attack. Subcutaneous, oral or intranasal administration in a daily dose.

It is excreted in breastmilk in clinically insignificant amounts (Wojnar 1996).

Its very low oral bioavailability impedes its transfer breastmilk to infant plasma, except in premature infants and the immediate neonatal period when there may be greater intestinal permeability.

Several medical assocoations, experts and expert consensus consider its use to be safe during breastfeeding (Hale 2019, Briggs 2017, Bordini 2016, Becker 2015, Amundsen 2015, Davanzo 2014, Worthington 2013, Hutchinson 2013, Duong 2010, Cassina 2010, Jürgens 2009, Marcus 2008, Raña 2008, MacGregor 2007, Loder 2007).

American Academy of Pediatrics: this medication is usually compatible with breastfeeding (AAP 2001).

Alternatives

We do not have alternatives for Sumatriptan since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Sumatriptan is also known as


Sumatriptan in other languages or writings:

Group

Sumatriptan belongs to this group or family:

Tradenames

Main tradenames from several countries containing Sumatriptan in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 14 %
Molecular weight 414 daltons
Protein Binding 14 - 21 %
VD 2,4 l/Kg
pKa 11,24 -
Tmax 0,2 hours
T1/2 1,3 - 2 hours
M/P ratio 4,9 -
Relative Dose 3,5 ( 0,3 - 6,7) %

References

  1. Hale TW. Hale's Medications & Mothers' Milk. Springer Publishing Company. 2019
  2. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. 11th edition (acces on line) 2017
  3. Bordini CA, Roesler C, Carvalho Dde S, Macedo DD, Piovesan É, Melhado EM, Dach F, Kowacs F, Silva Júnior HM, Souza JA, Maciel JA Jr, Carvalho JJ, Speciali JG, Barea LM, Queiroz LP, Ciciarelli MC, Valença MM, Lima MM, Vincent MB. Recommendations for the treatment of migraine attacks - a Brazilian consensus. Arq Neuropsiquiatr. 2016 Abstract Full text (link to original source) Full text (in our servers)
  4. Amundsen S, Nordeng H, Nezvalová-Henriksen K, Stovner LJ, Spigset O. Pharmacological treatment of migraine during pregnancy and breastfeeding. Nat Rev Neurol. 2015 Apr;11(4):209-19. Review. Abstract
  5. Becker WJ. Acute Migraine Treatment in Adults. Headache. 2015 Jun;55(6):778-93. Abstract
  6. Becker WJ. Acute Migraine Treatment. Continuum (Minneap Minn). 2015 Aug;21(4 Headache):953-72. Abstract
  7. Davanzo R, Bua J, Paloni G, Facchina G. Breastfeeding and migraine drugs. Eur J Clin Pharmacol. 2014 Abstract
  8. Hutchinson S, Marmura MJ, Calhoun A, Lucas S, Silberstein S, Peterlin BL. Use of common migraine treatments in breast-feeding women: a summary of recommendations. Headache. 2013 Abstract Full text (link to original source) Full text (in our servers)
  9. Worthington I, Pringsheim T, Gawel MJ, Gladstone J, Cooper P, Dilli E, Aube M, Leroux E, Becker WJ; Canadian Headache Society Acute Migraine Treatment Guideline Development Group. Canadian Headache Society Guideline: acute drug therapy for migraine headache. Can J Neurol Sci. 2013 Abstract Full text (in our servers)
  10. Duong S, Bozzo P, Nordeng H, Einarson A. Safety of triptans for migraine headaches during pregnancy and breastfeeding. Can Fam Physician. 2010 Abstract Full text (link to original source) Full text (in our servers)
  11. Cassina M, Di Gianantonio E, Toldo I, Battistella PA, Clementi M. Migraine therapy during pregnancy and lactation. Expert Opin Drug Saf. 2010 Nov;9(6):937-48. Abstract
  12. Jürgens TP, Schaefer C, May A. Treatment of cluster headache in pregnancy and lactation. Cephalalgia. 2009 Abstract
  13. Marcus DA. Managing headache during pregnancy and lactation. Expert Rev Neurother. 2008 Abstract
  14. Raña-Martínez N. Migraña en la mujer. [Migraine in females]. Rev Neurol. 2008 Abstract
  15. MacGregor EA. Migraine in pregnancy and lactation: a clinical review. J Fam Plann Reprod Health Care. 2007 Abstract Full text (in our servers)
  16. Loder E. Migraine in pregnancy. Semin Neurol. 2007 Abstract
  17. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  18. Wojnar-Horton RE, Hackett LP, Yapp P, Dusci LJ, Paech M, Ilett KF. Distribution and excretion of sumatriptan in human milk. Br J Clin Pharmacol. 1996 Abstract Full text (link to original source) Full text (in our servers)

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