Last update: July 16, 2017
Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
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Sodium salt of gamma-hydroxybutyric acid (GHBA), a natural body substance normally found in milk at levels of 0.1 - 1 mg / L.
It is used for the treatment of narcolepsy.
Given its rapid half-life, after 4 to 5 hours the GHBA levels in milk are back in the normal range.
Since it is administered in two evening doses at the beginning of the night (22:00 h and 02:00 h) breastfeeding is allowed even exclusively, taking care to wait 4 hours after the last dose. It would be advisable to pump breast milk during the day for using it at night time.
The intestinal drug absorption and plasma levels decrease significantly (up 58%) with simultaneous administration of a meal, especially if it has a high fat content.
They have not been observed problems in infants whose mothers were on this treatment. At least, one infant was exclusively breastfed for 6 months while her mother was taking sodium oxybate, fluoxetine and cetirizine with a pausing of 4 hours after each of the two doses of oxybate.
Oxybate does not alter prolactin levels.
We do not have alternatives for Sodium Oxybate.
Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
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