Last update: June 10, 2018

Sertaconazole Nitrate

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

An imidazole antifungal agent used topically as a skin cream or in the form of vaginal ovules.

Since the last update date we have not found published data on its excretion in breastmilk.

The mean plasma concentration after the application of 300 mg of vaginal sertaconazole was 1.79 ± 0.70 micrograms/L (Wang 2009).

Its insignificant or zero systemic absorption through vaginal mucosa or skin (Croxtall 2009, Wang 2009, Susilo 2006, Farré 1992) and its high plasma protein binding makes transfer to milk in significant quantities unlikely.

You should wash your hands well after application.

Do not apply on breast-nipple-areola or clean before breastfeeding.

Alternatives

We do not have alternatives for Sertaconazole Nitrate since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Sertaconazole Nitrate is also known as


Sertaconazole Nitrate in other languages or writings:

Pharmacokinetics

Variable Value Unit
Bioavailability baja - poor %
Molecular weight 501 daltons
Protein Binding 99 %
pKa 6,77 -
Tmax 7.0 ± 1.5 (vaginal) hours
T1/2 20.3 ± 9.1 hours

References

  1. Croxtall JD, Plosker GL. Sertaconazole: a review of its use in the management of superficial mycoses in dermatology and gynaecology. Drugs. 2009 Abstract
  2. Wang Y, Pang L, Wu M, Ou N. A validated LC-MS/MS method for determination of sertaconazole nitrate in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Abstract
  3. Susilo R, Korting HC, Greb W, Strauss UP. Nail penetration of sertaconazole with a sertaconazole-containing nail patch formulation. Am J Clin Dermatol. 2006 Abstract
  4. Farré M, Ugena B, Badenas JM, Márquez M, Roset P, Ortiz JA. Pharmacokinetics and tolerance of sertaconazole in man after repeated percutaneous administration. Arzneimittelforschung. 1992 Abstract

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