Last update: Feb. 20, 2016

Saccharin

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

Calcium saccharin and other related salts, sodium and potassium, are potent sweeteners.

They are excreted into breast milk in very small amount, which makes the infant may receive at most a dose of 0.26 mg / kg / day, which is well below the maximum recommended dose suggested by the FDA (5 mg / kg / day).

There is controversy on the genotoxic and carcinogenic effects of saccharin, since though when administered to animals it does appear genotoxicity at large doses, no evidence of its occurrence in human populations with regular consumption of saccharin has been found.

Moderate intake is compatible with breastfeeding.

Alternatives

We do not have alternatives for Saccharin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Saccharin is also known as


Saccharin in other languages or writings:

Group

Saccharin belongs to this group or family:

Tradenames

Main tradenames from several countries containing Saccharin in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 183 daltons
T1/2 4,8 hours
Theoretical Dose 0,26 mg/Kg/d
Relative Dose 5,2 %

References

  1. Sylvetsky AC, Gardner AL, Bauman V, Blau JE, Garraffo HM, Walter PJ, Rother KI. Nonnutritive Sweeteners in Breast Milk. J Toxicol Environ Health A. 2015 Abstract
  2. MedlinePlus. Edulcorantes y sustitutos del azúcar. Información de salud para usted. 2015 Full text (link to original source) Full text (in our servers)
  3. MedlinePlus. Sweeteners - sugar substitutes Trusted Health Information for you. 2015 Full text (link to original source) Full text (in our servers)
  4. Bosetti C, Gallus S, Talamini R, Montella M, Franceschi S, Negri E, La Vecchia C. Artificial sweeteners and the risk of gastric, pancreatic, and endometrial cancers in Italy. Cancer Epidemiol Biomarkers Prev. 2009 Abstract
  5. Nice FJ, Snyder JL, Kotansky BC. Breastfeeding and over-the-counter medications. J Hum Lact. 2000 Nov;16(4):319-31. Review. Erratum in: J Hum Lact 2001 Feb;17(1):90. Abstract
  6. Chappel CI. A review and biological risk assessment of sodium saccharin. Regul Toxicol Pharmacol. 1992 Abstract
  7. Egan PC, Marx CM, Heyl PS, et al. Saccharin concentration in mature human milk. Drug Intell Clin Pharm. 1984;18:511. Abstract. 1984

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