Last update: March 23, 2018

Phenolphthalein

Very High Risk for breastfeeding


Very unsafe. Contraindicated.
Use of an alternative or cessation of breastfeeding.

Derived from phenol with laxative properties by direct irritation via contact with the intestinal mucosa.

Since the last update we have not found published data on its excretion in breast milk.

Although intestinal absorption is only 15% (PubChem 2017), it may transfer to breastmilk and may cause diarrhea and other intestinal problems in the infant (PubChem 2017). Carcinogenic in animals and probably carcinogenic (2B) in humans (WHO 2000, EMA 1997).

It has been withdrawn from sale in most countries.

Bulk-forming, osmotic, emollient or lubricant laxatives are safer.

In order to avoid or treat constipation, a balanced diet, rich in fibre, with lots of liquid and sports is fundamental.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Phenolphthalein in other languages or writings:

Group

Phenolphthalein belongs to this group or family:

Tradenames

Main tradenames from several countries containing Phenolphthalein in its composition:

  • Alin
  • Anson™. Contains other elements than Phenolphthalein in its composition
  • Beagarol™. Contains other elements than Phenolphthalein in its composition
  • Coslax™. Contains other elements than Phenolphthalein in its composition
  • Doce Alivio™. Contains other elements than Phenolphthalein in its composition
  • Emulax™. Contains other elements than Phenolphthalein in its composition
  • Fenokomp 39™. Contains other elements than Phenolphthalein in its composition
  • Fructines (Argentina)
  • Genolaxante™. Contains other elements than Phenolphthalein in its composition
  • Heroanson™. Contains other elements than Phenolphthalein in its composition
  • Jaglax
  • Laksafenol
  • Laxadine™. Contains other elements than Phenolphthalein in its composition
  • Oblax A-1-1™. Contains other elements than Phenolphthalein in its composition
  • Paralax™. Contains other elements than Phenolphthalein in its composition
  • Taeniacide™. Contains other elements than Phenolphthalein in its composition
  • Zenda™. Contains other elements than Phenolphthalein in its composition

Pharmacokinetics

Variable Value Unit
Bioavailability 15 %
Molecular weight 318 daltons

References

  1. PubChem. Phenolphthalein. Compound Summary. 2017 Full text (link to original source) Full text (in our servers)
  2. WHO. International Agency for research on Cancer. PHENOLPHTHALEIN. IARC monographs on the evaluation of carcinogenic risks to humans. Vol.76-15. 2000 Full text (link to original source) Full text (in our servers)
  3. WHO. International Agency for research on Cancer. PHENOLPHTHALEIN. Summary of final evaluations. IARC monographs on the evaluation of carcinogenic risks to humans. Vol.76-17. 2000 Full text (link to original source) Full text (in our servers)
  4. EMA. Genotoxic and carcinogenic potential of phenolphthalein Position Paper 1997 Full text (link to original source) Full text (in our servers)

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