Last update: June 12, 2019


Low Risk for breastfeeding

Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

Sympathomimetic drug that is topically used for treatment of nose or the eye.

On last update no relevant published data related to breastfeeding were found.

Nasal use: Avoid high dosing and do not use for longer than 3 days: as an adrenergic agonist drug it could be absorbed and a cause of side effects (vascular hypertension or hypotension, irritability, heart arrhythmia) in both the mother and the infant.
Long term maintained doses may decrease milk production.

Low risk in Ophthalmologic use: A small dose together with a low plama level of most nasal and ophthalmologic compounds make that a significant excretion into breast milk would be unlikely.


Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Naphazoline is also known as

Naphazoline in other languages or writings:


Main tradenames from several countries containing Naphazoline in its composition:


Variable Value Unit
Molecular weight 247 daltons
T1/2 4 - 12 hours


  1. Redaction Prescrire. Pour mieux soigner, des médicaments à écarter : bilan 2018. 2018 Full text (link to original source) Full text (in our servers)
  2. Díaz M, Granson E, Taiman J, Alava J, Gabrielli T, Mendoza L. [Severe poisoning with naphazoline: update from a therapeutic error]. Arch Argent Pediatr. 2018 Aug 1;116(4):e626-e629. Abstract
  3. Nice FJ, Snyder JL, Kotansky BC. Breastfeeding and over-the-counter medications. J Hum Lact. 2000 Nov;16(4):319-31. Review. Erratum in: J Hum Lact 2001 Feb;17(1):90. Abstract
  4. Anderson PO. Decongestants and milk production. J Hum Lact. 2000 Abstract
  5. Paricio JM, Benlloch MJ, Llobat T, Santos L, Grieco M, Martín J, Soler E, Cuenca A. Intoxicación por tetraborato de sodio y nafazolina (euboral oftálmico). A propósito de un caso. Rev Esp Pediatr 1993;49:281–282. Full text (in our servers)

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