Last update: Feb. 10, 2019
Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.
A short-acting sulfonamide with similar properties to sulfamethoxazole. Rarely administered systemically due to its toxicity (Toxnet 2009).
Used topically along with other medications for the treatment of vaginal, dermatological, ocular, otic and gastrointestinal infections.
Since the last update we have not found published data on its excretion in breastmilk.
Sulfonamides are excreted in small amounts in breastmilk: 6 to 94 micrograms/ml, 1.6% of the total dose (Briggs 2017). Reports of adverse effects are rare.
An old publication reports cases of diarrhea and rash in children breastfed by mothers who were being treated with sulfathiazole. (Von Freissen 1951).
Sulfathiazole is absorbed in very small amounts through the dermis (Waud 1944) and the intestine (Lasca 2018).
The small dose and poor plasma absorption of most topical ophthalmological, otic and dermatological preparations make it unlikely that significant amounts will transfer into breastmilk.
Do not apply to the chest in order to prevent the infant from ingesting it; if necessary, apply after a feed and clean well with water before the next one.
We do not have alternatives for N1-(1,3-Thiazol-2-yl)sulphanilamide.
Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.
Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.
Thank you for helping to protect and promote breastfeeding.
e-lactancia is a resource recommended by Academy of Breastfeeding Medicine from United States of America
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM