Last update: July 23, 2016
Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
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Antiprogestin which derives from Norethisterone that is used for abortion, both as an abortifacient and induction of labor.
Its high plasma protein-binding capacity explains that excretion into breast milk is clinically non-significant. It achieves very low levels in breast milk at a maternal dose of 600 mg or undetectable at maternal dose of 200 mg.
Mifepristone does not interfere with the secretion of Prolactin. Some authors found that it may facilitate the early initiation of breastfeeding.
As in addition it is usually used for short periods, stopping breastfeeding is not required.
When used with semi-experimental purposes due to its anti-androgenic and antiglucocorticoid properties a continuous administration and / or large doses is required. There is no experience in connection with breastfeeding.
Those pathologies in which it is often used on a continuous basis by themselves are not compatible with breastfeeding.
We do not have alternatives for Mifepristone.
Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
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