Last update: Nov. 3, 2018
Minimal risk for breastfeeding and infant.
Metronidazole is used topically in the treatment of acne (Kong 2013) and vaginitis.
Metronidazole, when taken orally, is excreted in small amounts in breastmilk (Zhang 1997, Passmore 1988, Heisterberg 1983, Erickson 1981, Gray 1961) and does not cause problems in infants (Passmore 1988, Gray 1961), and is considered compatible with breastfeeding.
The low content in topical preparations (<1% metronidazole) and its poor absorption through skin or vaginal mucosa makes it unlikely that it transfers to breastmilk in significant amounts.
Compared with oral administration, the plasma levels reached are 1% through the skin and 2% through the vagina (AEMPS 2018, Sanofi 2018, FDA 2005, AEMPS 2001) and is considered even more compatible with breastfeeding than via systemic administration (Rowe 2013, Kong 2013).
We do not have alternatives for Metronidazole (Dermal and Vaginal use) since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.
Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.
Thank you for helping to protect and promote breastfeeding.
e-lactancia is a resource recommended by Confederación Nacional de Pediatría (CONAPEME) from Mexico
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM