Last update: Feb. 11, 2019

Methenamine

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

An antibacterial used in the long-term prophylaxis and treatment of recurrent lower urinary tract infections (bladder) and asymptomatic bacteriuria.
Oral administration 2 to 4 times a day.

It is excreted in breastmilk in clinically insignificant amounts and no problems have been observed in infants whose mothers were taking it (Allgen 1979).

Several expert authors consider it safe or probably safe to use this medication during breastfeeding (Lactmed 2018, Hale 2017 p 624, Briggs 2017).

Exposure can be minimized by waiting to breastfeed three hours after taking the drug (Mactal 2001).

Alternatives

We do not have alternatives for Methenamine.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Methenamine is also known as


Methenamine in other languages or writings:

Group

Methenamine belongs to this group or family:

Tradenames

Main tradenames from several countries containing Methenamine in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 140 daltons
Tmax 1 - 2 hours
T1/2 3 - 4 hours
M/P ratio 1 -
Theoretical Dose 0,65 - 1,37 mg/Kg/d
Relative Dose 3,9 - 8,2 %

References

  1. LactMed. Methenamine. Drugs and Lactation Database. 2018 Abstract
  2. Hale TW, Rowe HE. Medications & Mothers' Milk. A Manual of Lactation Pharmacology. Springer Publishing Company. 2017
  3. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. 11th edition (acces on line) 2017
  4. Mactal-Haaf C, Hoffman M, Kuchta A. Use of anti-infective agents during lactation, Part 3: Antivirals, antifungals, and urinary antiseptics. J Hum Lact. 2001 Abstract
  5. Allgén LG, Holmberg G, Persson B, Sörbo B. Biological fate of methenamine in man. Absorption, renal excretion and passage to umbilical cord blood, amniotic fluid and breast milk. Acta Obstet Gynecol Scand. 1979 Abstract

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