Last update: Dec. 29, 2014

Melatonin

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

Hormone secreted by Pineal gland which exerts its function by regulating the Circadian pattern of sleeping. It is naturally found in the mother's milk.

The level of Melatonin in the plasma and breast milk increases by night. It is believed that helps to organize the sleep - awake cycle in breastfed newborns and infants.

It has antioxidant and anti-inflammatory properties, and, it is found in many foods, either vegetable or animal in origin (meat, fish), eggs, wine and beer.

On latest update, no relevant published data related to breastfeeding were found, however, known side-effects are mild and few. It is being used for co-treatment of several conditions in newborn infants and prematures, with good tolerance in spite of higher doses than those excreted in the breast milk.

Alternatives

We do not have alternatives for Melatonin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Melatonin is also known as


Group

Melatonin belongs to this group or family:

Tradenames

Main tradenames from several countries containing Melatonin in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 16 (1 -37) %
Molecular weight 232 daltons
Tmax 0,5 - 2 hours
T1/2 0,6 - 0,7 hours
M/P ratio 0,4 - 0,8 -

References

  1. Amer MR, Cipriano GC, Venci JV, Gandhi MA. Safety of Popular Herbal Supplements in Lactating Women. J Hum Lact. 2015 Abstract
  2. Tan DX, Zanghi BM, Manchester LC, Reiter RJ. Melatonin identified in meats and other food stuffs: potentially nutritional impact. J Pineal Res. 2014 Abstract
  3. Merchant NM, Azzopardi DV, Hawwa AF, McElnay JC, Middleton B, Arendt J, Arichi T, Gressens P, Edwards AD. Pharmacokinetics of melatonin in preterm infants. Br J Clin Pharmacol. 2013 Abstract
  4. Gitto E, Marseglia L, Manti S, D'Angelo G, Barberi I, Salpietro C, Reiter RJ. Protective role of melatonin in neonatal diseases. Oxid Med Cell Longev. 2013 Abstract
  5. Cohen Engler A, Hadash A, Shehadeh N, Pillar G. Breastfeeding may improve nocturnal sleep and reduce infantile colic: potential role of breast milk melatonin. Eur J Pediatr. 2012 Abstract
  6. EMA. Melatonina. Ficha técnica. 2012 Full text (in our servers)
  7. EMA. Melatonin. Drug Summary. 2012 Full text (in our servers)
  8. Sánchez-Barceló EJ, Mediavilla MD, Reiter RJ. Clinical uses of melatonin in pediatrics. Int J Pediatr. 2011 Abstract
  9. Chen LH, Zeind C, Mackell S, LaPointe T, Mutsch M, Wilson ME. Breastfeeding travelers: precautions and recommendations. J Travel Med. 2010 Jan-Feb;17(1):32-47. Abstract Full text (link to original source) Full text (in our servers)
  10. Nice FJ, Snyder JL, Kotansky BC. Breastfeeding and over-the-counter medications. J Hum Lact. 2000 Nov;16(4):319-31. Review. Erratum in: J Hum Lact 2001 Feb;17(1):90. Abstract
  11. DeMuro RL, Nafziger AN, Blask DE, Menhinick AM, Bertino JS Jr. The absolute bioavailability of oral melatonin. J Clin Pharmacol. 2000 Abstract
  12. Fourtillan JB, Brisson AM, Gobin P, Ingrand I, Decourt JP, Girault J. Bioavailability of melatonin in humans after day-time administration of D(7) melatonin. Biopharm Drug Dispos. 2000 Abstract
  13. Illnerová H, Buresová M, Presl J. Melatonin rhythm in human milk. J Clin Endocrinol Metab. 1993 Abstract

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