Last update: Jan. 4, 2021

Levobunolol Hydrochloride

Low Risk for breastfeeding

Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

It is a non-cardioselective beta blocker
It is used in the treatment of glaucoma and ocular hypertension,
Topical administration as eye drops, one drop every 12 to 24 hours.

Since the last update we have not found any published data on its excretion in breast milk.

Its pharmacokinetic characteristics (large volume of distribution and high pKA), make it very unlikely its excretion into breast milk in significant amounts.

Absorption should be minimized by closing the eye after instillation, applying pressure for 1 to 5 minutes with your finger on the tear duct at the inner corner of the eye and administering the dose immediately after nursing (Blumen 2020, Belkin 2020, Méndez 2012, Johnson 2001).

Until there is further published data on this drug in relation to breastfeeding, known safer alternatives may be preferable, especially during the neonatal period and in cases of prematurity.


Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Levobunolol Hydrochloride in other languages or writings:


Levobunolol Hydrochloride belongs to this group or family:


Main tradenames from several countries containing Levobunolol Hydrochloride in its composition:


Variable Value Unit
Oral Bioavail. 80 %
Molecular weight 328 daltons
VD 5,5 l/Kg
pKa 14,09 -
Tmax 3 hours
T1/2 6 - 8 hours


  1. Blumen-Ohana E, Sellem E. Grossesse & glaucome : recommandations SFO—SFG. [Pregnancy & glaucoma: SFO-SFG recommendations]. J Fr Ophtalmol. 2020 Jan;43(1):63-66. Abstract
  2. Belkin A, Chen T, DeOliveria AR, Johnson SM, Ramulu PY, Buys YM; American Glaucoma Society and the Canadian Glaucoma Society.. A Practical Guide to the Pregnant and Breastfeeding Patient with Glaucoma. Ophthalmol Glaucoma. 2020 Mar - Apr;3(2):79-89. Abstract
  3. Teva. Levobunolol. Drug Summary. 2013 Full text (in our servers)
  4. Méndez-Hernández C. Uso de fármacos antiglaucomatosos durante el embarazo y lactancia. [Use of glaucoma medications during pregnancy and breastfeeding]. Arch Soc Esp Oftalmol. 2012 Dec;87(12):389-91. Abstract
  5. Johnson SM, Martinez M, Freedman S. Management of glaucoma in pregnancy and lactation. Surv Ophthalmol. 2001 Mar-Apr;45(5):449-54. Abstract

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