Last update: March 22, 2018

クロトリマゾール

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Excretion into breast milk is very unlikely since absorption through skin, vaginal mucosa, and, even intestinal mucosa into plasma is very poor with non-significant plasma levels or below the detection threshold (<10 ng/mL). In addition, because of a high plasma protein binding capacity, excretion into breast milk seems to be less likely.

It is used frequently for treatment of Candida infection, either in skin or mouth mucosa, even in newborn and premature infants without observed side-effects.

In case of use on the nipple, do it after feeding the baby and cleanse thoroughly the surface before the next one.

Do not use creams, gels and other locally applied products that contain paraffin (mineral oil) to prevent absorption by the infant.

Alternatives

We do not have alternatives for クロトリマゾール since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
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Other names

クロトリマゾール is Clotrimazole in Japanese.

Is written in other languages:

Groups

クロトリマゾール belongs to these groups or families:

Tradenames

Main tradenames from several countries containing クロトリマゾール in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 3 - 10 %
Molecular weight 345 daltons
Protein Binding 90 %
Tmax 3 hours
T1/2 2 hours

References

  1. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014 Mar;70(3):417.e1-10; quiz 427. Abstract
  2. MSyC-AgEspMed. Clotrimazol. Ficha técnica. 2014 Full text (in our servers)
  3. New Zealand Data Sheet. Clotrimazole. Data Sheet. 2013 Full text (in our servers)
  4. Andersson M, Helldén A. Behandling av bröstvårtesvamp ­hos ammande kvinnor. \ [Treatment of nipple candidiasis in breast feeding mothers]. Lakartidningen. 2010 Abstract Full text (link to original source) Full text (in our servers)
  5. Hoeger PH, Stark S, Jost G. Efficacy and safety of two different antifungal pastes in infants with diaper dermatitis: a randomized, controlled study. J Eur Acad Dermatol Venereol. 2010 Abstract
  6. Andersson M, Helldén A. [Treatment of nipple candidiasis in breast feeding mothers]. Lakartidningen. 2010 Abstract
  7. Chen LH, Zeind C, Mackell S, LaPointe T, Mutsch M, Wilson ME. Breastfeeding travelers: precautions and recommendations. J Travel Med. 2010 Jan-Feb;17(1):32-47. Abstract Full text (link to original source) Full text (in our servers)
  8. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008 Abstract
  9. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003 Abstract
  10. Mactal-Haaf C, Hoffman M, Kuchta A. Use of anti-infective agents during lactation, Part 3: Antivirals, antifungals, and urinary antiseptics. J Hum Lact. 2001 Abstract
  11. Dhondt F, Ninane J, De Beule K, Dhondt A, Cauwenbergh G. Oral candidosis: treatment with absorbable and non-absorbable antifungal agents in children. Mycoses. 1992 Abstract
  12. Johnstone HA, Marcinak JF. Candidiasis in the breastfeeding mother and infant. J Obstet Gynecol Neonatal Nurs. 1990 Abstract
  13. Lücker PW, Beubler E, Kukovetz WR, Ritter W. Retention time and concentration in human skin of bifonazole and clotrimazole. Dermatologica. 1984 Abstract
  14. Sitka U, Weingärtner L. [Clotrimazol in the treatment of candida infections in premature and newborn children (author's transl)]. Med Klin. 1976 Abstract
  15. Cohen M, Harkness RA, Renz M, Farquhar JW. Trials of the use of clotrimazole in the treatment of oral candidiasis in newborn babies. Postgrad Med J. 1974 Abstract

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