Last update: May 13, 2019
Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
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A mixture of macrogol ethers. An anionic surfactant detergent with sclerosing properties on varicose veins.
Administration by local injections in the vein to be sclerosed.
It contains 5% alcohol.
Since the last update we have not found any published data on its excretion in breast milk.
After local injections, low plasma levels have been detected in some patients (FDA 2010). Its moderately high molecular weight, large volume of distribution and short half-life (AEMPS 2017, FDA 2010) would hinder transfer into breastmilk.
Several experts believe that the use of this medication is probably compatible during breastfeeding (Briggs 2017, Hale 2017 p784).
Due to the lack of accurate pharmacokinetic data and given that after 5 half-lives of elimination (5 T½), 97% of a substance is eliminated from the body (Anderson 2016), it may be prudent, in order to minimize any possible exposure, to stop breastfeeding between 7 - 8 hours after the last sclerosing injection. However, the manufacturer advises a waiting period of 2 to 3 days (AEMPS 2017) which seems excessive since it is not based on the pharmacokinetics of the product.
We do not have alternatives for 聚桂醇400.
Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
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