Last update: May 1, 2016

Hydroxychloroquine Sulfate

Very Low Risk for breastfeeding

Safe. Compatible.
Minimal risk for breastfeeding and infant.

Antimalarial drug used as anti-inflammatory and immunomodulating agent on tissue diseases such as arthritis or lupus.

It is excreted in breast milk in clinically non-significant amount which is much lower than the dose used in infants. Problems related to clinical features, development, vision or hearing issues have not been observed in infants whose mothers have received this medication.

When the mother takes 400 mg per day only 1 mg appears for every liter of milk, which is not considered dangerous to the infant, since a preventive dose for malaria in infants is 5 mg per kilo of weight once a week.

American Academy of Pediatrics states that it is usually compatible with breastfeeding medication.


We do not have alternatives for Hydroxychloroquine Sulfate since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Hydroxychloroquine Sulfate in other languages or writings:


Hydroxychloroquine Sulfate belongs to this group or family:


Main tradenames from several countries containing Hydroxychloroquine Sulfate in its composition:


Variable Value Unit
Oral Bioavail. 74 %
Molecular weight 434 daltons
Protein Binding 63 %
VD 580 - 815 l/Kg
Tmax 1 - 2 hours
T1/2 768 - 1200 hours
M/P ratio 5,5 -
Theoretical Dose 0,06 - 0,2 mg/Kg/d
Relative Dose 0,9 - 3 %
Relat.Ped.Dose 0,4 - 6,6 %


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  7. Costedoat-Chalumeau N, Dunogué B, Morel N, Le Guern V, Guettrot-Imbert G. Hydroxychloroquine: a multifaceted treatment in lupus. Presse Med. 2014 Abstract
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  16. Costedoat-Chalumeau N, Amoura Z, Huong DL, Lechat P, Piette JC. Safety of hydroxychloroquine in pregnant patients with connective tissue diseases. Review of the literature. Autoimmun Rev. 2005 Abstract
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