Last update: Dec. 23, 2020

Hydrastis

Increased level of risk

New scientific evidences have driven the Apilam staff to update the level of risk associated to this product.
Former level of risk, which was Low Risk, is now set to High Risk.

Level of risk reviewed on Dec. 21, 2020

High Risk for breastfeeding


Poorly safe. Evaluate carefully.
Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives).
Read the Comment.

La raíz de esta planta contiene alcaloides bencilisoquinoleinicos: hidrastina, berberina y canadina (ESCOP 2013) en concentraciones que pueden ser extremadamente variables (Edwards 2003).
En medicina tradicional se utiliza como cicatrizante, vasoprotector, digestivo y antiséptico.
Adminsitración oral o tópica sobre la piel, mucos bucal y ojos.
Nota: esta planta no tiene ninguna relación con la cúrcuma (Curcuma longa, cúrcuma india).

A fecha de última actualización no encontramos datos publicados sobre su excreción en leche materna.

Se ha comprobado la asociación de su consumo con efectos secundarios como hipertensión (McCarty 2013) y fototoxicidad (Chignell 2007, Palanisamy 2003, Inbaraj 2001) e intoxicación hipernatrémica en una niña de 11 años (Bhowmick 2007).
El uso crónico tiene efectos carcinógenos en animales (Chen 2013, Dunnick 2013, NTP 2010).

La berberina puede provocar gastritis, nefritis, fototoxicidad e ictericia grave por desplazamiento de la bilirrubina ligada a la albumina: riesgo de kernicterus en recién nacidos, mayor en caso de déficit de Glucosa-6PD (Rad 2017, Chan 1993).

Dadas las escasas referencias bibliográficas de esta planta, su falta de indicaciones comprobadas y su posible toxicidad, su consumo habitual es prescindible y más durante la lactancia (ESCOP 2013, Amir 2011, WHO 2007).

Precauciones al tomar preparados de plantas (Anderson 2017, Powers 2015, Posadzki 2013, Efferth 2011, Kopec 1999):

1. Asegurarse que son de fuente fiable: Han ocurrido intoxicaciones por confusión de una planta con otra con propiedades tóxicas, envenenamientos por contener metales pesados que extraen del suelo y toxiinfecciones alimentarias por contaminación con bacterias u hongos . 
2. No tomar en exceso; seguir recomendaciones de profesionales expertos en fitoterapia. Los productos “naturales” no son buenos en cualquier cantidad: las plantas contienen sustancias activas de las que se ha obtenido gran parte de nuestra farmacopea tradicional y pueden provocar intoxicaciones o actuar como disruptores endocrinos por contiener fitoestrógenos si se consumen en cantidad o tiempo exagerados.


See below the information of these related products:

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Groups

Hydrastis belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Hydrastis in its composition:

  • Digestive™. Contains other elements than Hydrastis in its composition

Pharmacokinetics

Variable Value Unit
Tmax Hidrastine: 1.5 ± 0.3 hours
T1/2 Hidrastine: 4.8 ± 1.4 hours

References

  1. Mandal SK, Maji AK, Mishra SK, Ishfaq PM, Devkota HP, Silva AS, Das N. Goldenseal (Hydrastis canadensis L.) and its active constituents: A critical review of their efficacy and toxicological issues. Pharmacol Res. 2020 Oct;160:105085. Abstract
  2. Anderson PO. Herbal Use During Breastfeeding. Breastfeed Med. 2017 Abstract
  3. Rad SZK, Rameshrad M, Hosseinzadeh H. Toxicology effects of Berberis vulgaris (barberry) and its active constituent, berberine: a review. Iran J Basic Med Sci. 2017 May;20(5):516-529. Abstract
  4. Powers CN, Setzer WN. A molecular docking study of phytochemical estrogen mimics from dietary herbal supplements. In Silico Pharmacol. 2015 Mar 22;3:4. Abstract Full text (link to original source) Full text (in our servers)
  5. Gupta PK, Barone G, Gurley BJ, Fifer EK, Hendrickson HP. Hydrastine pharmacokinetics and metabolism after a single oral dose of goldenseal (Hydrastis canadensis) to humans. Drug Metab Dispos. 2015 Apr;43(4):534-52. Abstract
  6. Chen S, Wan L, Couch L, Lin H, Li Y, Dobrovolsky VN, Mei N, Guo L. Mechanism study of goldenseal-associated DNA damage. Toxicol Lett. 2013 Jul 31;221(1):64-72. Abstract
  7. Posadzki P, Watson L, Ernst E. Contamination and adulteration of herbal medicinal products (HMPs): an overview of systematic reviews. Eur J Clin Pharmacol. 2013 Abstract
  8. ESCOP - European Scientific Cooperative on Phytotherapy. Hydrastis rhizoma - Goldenseal rhizome. ESCOP Monographs. 2013 Full text (link to original source) Full text (in our servers)
  9. Dunnick JK, Nyska A. The toxicity and pathology of selected dietary herbal medicines. Toxicol Pathol. 2013 Feb;41(2):374-86. Abstract
  10. McCarty CA, Berg RL, Rottscheit CM, Dart RA. The use of dietary supplements and their association with blood pressure in a large Midwestern cohort. BMC Complement Altern Med. 2013 Nov 28;13:339. Abstract
  11. Mannion C, Mansell D. Breastfeeding self-efficacy and the use of prescription medication: a pilot study. Obstet Gynecol Int. 2012;2012:562704. Abstract Full text (link to original source) Full text (in our servers)
  12. Amir LH, Pirotta MV, Raval M. Breastfeeding--evidence based guidelines for the use of medicines. Aust Fam Physician. 2011 Sep;40(9):684-90. Review. Abstract Full text (link to original source) Full text (in our servers)
  13. Efferth T, Kaina B. Toxicities by herbal medicines with emphasis to traditional Chinese medicine. Curr Drug Metab. 2011 Abstract
  14. NTP - National Toxicology Program.. Toxicology and carcinogenesis studies of goldenseal root powder (Hydrastis Canadensis) in F344/N rats and B6C3F1 mice (feed studies). Natl Toxicol Program Tech Rep Ser. 2010 Aug;(562):1-188. Abstract
  15. Chignell CF, Sik RH, Watson MA, Wielgus AR. Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.) 3: effect on human lens and retinal pigment epithelial cells. Photochem Photobiol. 2007 Jul-Aug;83(4):938-43. Abstract
  16. WHO. World Health Organization. Geneva. WHO monographs on selected medicinal plants. Volume 3. p 338-348. WHO monographs. 2007 Full text (link to original source) Full text (in our servers)
  17. Bhowmick SK, Hundley OT, Rettig KR. Severe hypernatremia and hyperosmolality exacerbated by an herbal preparation in a patient with diabetic ketoacidosis. Clin Pediatr (Phila). 2007 Nov;46(9):831-4. Epub 2007 Jun 21. Abstract
  18. Palanisamy A, Haller C, Olson KR. Photosensitivity reaction in a woman using an herbal supplement containing ginseng, goldenseal, and bee pollen. J Toxicol Clin Toxicol. 2003;41(6):865-7. Abstract
  19. Edwards DJ, Draper EJ. Variations in alkaloid content of herbal products containing goldenseal. J Am Pharm Assoc (2003). 2003 May-Jun;43(3):419-23. Abstract
  20. Inbaraj JJ, Kukielczak BM, Bilski P, Sandvik SL, Chignell CF. Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.) 1. Berberine. Chem Res Toxicol. 2001 Nov;14(11):1529-34. Abstract
  21. Kopec K. Herbal medications and breastfeeding. J Hum Lact. 1999 Jun;15(2):157-61. Review. No abstract available. Abstract
  22. Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate. 1993;63(4):201-8. Abstract

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