Last update: Oct. 9, 2016

Gramicidin

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Polypeptide with antibacterial properties which is isolated along with tyrothricin through fermentation of Bacillus brevis.
Topically used on mucocutaneous and eye infections often in association with other antibacterial drugs such as Neomycin, Polymyxin B and others like Corticosteroids or Benzocaine.

It is highly toxic when systemically used. It has been withdrawn from the market in some countries due to lack of therapeutic effectiveness.

Given its negligible systemic absorption and high molecular weight, excretion into breastmilk is highly unlikely.

Do not apply on the breast to prevent ingestion by the infant.

Alternatives

We do not have alternatives for Gramicidin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Gramicidin in other languages or writings:

Tradenames

Main tradenames from several countries containing Gramicidin in its composition:

  • Flodermol™. Contains other elements than Gramicidin in its composition
  • Midacina™. Contains other elements than Gramicidin in its composition
  • Neosporin™. Contains other elements than Gramicidin in its composition
  • Oftalmowell™. Contains other elements than Gramicidin in its composition
  • Septilisin™. Contains other elements than Gramicidin in its composition
  • Sofradex™. Contains other elements than Gramicidin in its composition

Pharmacokinetics

Variable Value Unit
Oral Bioavail. baja - Poor %
Molecular weight 1.882 daltons

References

  1. AEMPS. Oftalmowell. Ficha técnica. 2013 Full text (in our servers)
  2. WHO Pharmaceuticals Newsletter. 2005 Full text (link to original source) Full text (in our servers)

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e-lactancia is a resource recommended by Instituto de Salud Infantil, Grecia-Institute of Child's Health in Greece

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