Last update: March 9, 2019

Follicle-stimulating Hormone (FSH)

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

Follicle stimulating hormone (FSH) or follitropin is a gonadotropin type hormone produced by the human body. It is a glycopolypeptide which is synthesized and secreted by gonadotroph cells from the anterior part of the pituitary gland.
FSH regulates pubertal maturation and it stimulates the maturation of oocytes in the ovary and the production of estradiol (estrogenic hormone) in women. It regulates the production of sperm in men.

There are human follitropin preparations (urofollitropin from human menopausal gonadotropin (HMG)) while others are obtained from recombinant engineering (follitropin alpha, beta and delta and Corifollitropin alfa) with similar effectiveness and uses (Weiss 2019, Taketani 2010, Baker 2009).

FSH or follitropin is commonly used alone or together with luteinizing hormone (LH) in infertility treatments to induce ovulation in anovulatory patients who do not respond to clomiphene and to stimulate the development of multiple follicles (ovarian hyperstimulation) in ovulatory patients during assisted reproduction protocols.
Human chorionic gonadotropin hormone (HCG) is usually administered afterwards to trigger ovulation.
Subcutaneous or intramuscular administration is given daily in one dose and is followed by an ovarian ultrasonographic evaluation or by a measurement of urinary estrogen after 10 to 35 days, depending on the indication.

At date of this last update we did not find published data regarding its excretion in breast milk.

Due to its high molecular weight it is very unlikely to be excreted in breast milk.

Due to its glycoprotein nature it is inactivated in the gastrointestinal tract without being absorbed (oral bioavailability practically null). This hinders or prevents the passage to infant plasma from ingested breast milk, except in the case of premature babies and during the immediate neonatal period, in which there may be greater intestinal permeability.

It is not proven that its estrogenic effect decreases milk production.

LACTATION AND INFERTILITY TREATMENTS
In assisted reproduction treatments (ART) for infertility, two issues must be taken into account:

1. The possible effects of ART on the infant or lactation.
The medications generally used do not interfere with breastfeeding and do not affect the infant. Also, during this treatments, lactating children tend to be older than 6 months and usually above 1 year of age.

2. Possible interference of breastfeeding with ART.
Breastfeeding, especially when its frequent, could hinder ovulation. Treatments tend to be financially and emotionally costly and therefore assisted reproduction services usually recommend suspending breastfeeding before starting any treatment protocols.

To date there is no published data showing that breastfeeding is incompatible with assisted reproduction techniques (ART).


See below the information of these related products:

Alternatives

We do not have alternatives for Follicle-stimulating Hormone (FSH).

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Follicle-stimulating Hormone (FSH) is also known as


Follicle-stimulating Hormone (FSH) in other languages or writings:

Group

Follicle-stimulating Hormone (FSH) belongs to this group or family:

Tradenames

Main tradenames from several countries containing Follicle-stimulating Hormone (FSH) in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 22.673 daltons
VD 0,13 l/Kg
Tmax 8 - 16 hours
T1/2 35 (12 - 70) hours

References

  1. Weiss NS, Kostova E, Nahuis M, Mol BWJ, van der Veen F, van Wely M. Gonadotrophins for ovulation induction in women with polycystic ovary syndrome. Cochrane Database Syst Rev. 2019 Jan 16;1:CD010290. Abstract
  2. AEMPS-MSD. Folitropina. Ficha técnica. 2014 Full text (in our servers)
  3. EMD Serono. Follitropin. Drug Summary. 2012 Full text (in our servers)
  4. Taketani Y, Kelly E, Yoshimura Y, Hoshiai H, Irahara M, Mizunuma H, Saito H, Andoh K, Yanaihara T. Recombinant follicle-stimulating hormone (follitropin alfa) versus purified urinary follicle-stimulating hormone in a low-dose step-up regimen to induce ovulation in Japanese women with anti-estrogen-ineffective oligo- or anovulatory infertility: results of a single-blind Phase III study. Reprod Med Biol. 2010 Feb 23;9(2):99-106. Abstract
  5. MSD. Follitropin. Drug Summary. 2009 Full text (in our servers)
  6. Baker VL, Fujimoto VY, Kettel LM, Adamson GD, Hoehler F, Jones CE, Soules MR. Clinical efficacy of highly purified urinary FSH versus recombinant FSH in volunteers undergoing controlled ovarian stimulation for in vitro fertilization: a randomized, multicenter, investigator-blind trial. Fertil Steril. 2009 Apr;91(4):1005-11. Abstract
  7. Bonnar J, Franklin M, Nott PN, McNeilly AS. Effect of breast-feeding on pituitary-ovarian function after childbirth. Br Med J. 1975 Oct 11;4(5988):82-4. Abstract

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