Last update: June 4, 2016

Flutrimazole

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

At latest update no published data on excretion into breast milk were found.

Excretion into breast milk is highly unlikely due to the low absorption through the skin (1%) or vaginal mucosa (8%) and hence a low presence into the blood.

Whenever used on the nipple apply it after feeding and remove excess of cream before the next meal.

It should be avoided the use on the nipple of creams, gels and other products for local application containing paraffin (mineral oil) to keep the infant off from absorption.

Alternatives

We do not have alternatives for Flutrimazole since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Flutrimazole in other languages or writings:

Tradenames

Main tradenames from several countries containing Flutrimazole in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 1 (dermat) %
Molecular weight 346 daltons
Tmax 28 hours
T1/2 37 hours

References

  1. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008 Abstract
  2. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003 Abstract
  3. John B, Wood SG, Ramis J, Izquierdo I, Forn J. Absorption and excretion of radioactivity after intravaginal administration of an advanced delivery system of 14C-flutrimazole vaginal cream to postmenopausal women. Arzneimittelforschung. 1998 Abstract
  4. Ramis J, Conte L, Segado X, Forn J, Lauroba J, Calpena A, Escribano E, Domenech J. Influence of formulation on the in vitro transdermal penetration of flutrimazole. Arzneimittelforschung. 1997 Abstract
  5. Duchène P, Papalexiou P, Ramis J, Izquierdo I, Houin G. Pharmacokinetic profile of [14C]flutrimazole following single topical application in normal and scarified skin of healthy volunteers. Arzneimittelforschung. 1992 Abstract

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e-lactancia is a resource recommended by Instituto de Salud Infantil, Grecia-Institute of Child's Health in Greece

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