Last update: Jan. 26, 2021

Etilefrine Hydrochloride

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

Adrenergic sympathomimetic agent used in the treatment of orthostatic hypotension and cardiovascular syncope.
Oral or intravenous administration.

Since the last update we have not found any published data on its excretion in breast milk.

Its short half-life make transfer into breastmilk in significant quantities unlikely.
Its low oral bioavailability would make it difficult its passage to the infant’s plasma through breast milk except in premature babies and in the immediate neonatal period during which there may be greater intestinal permeability.

Trendelemburg position, may produce the same clinical improvement as (empiric) ethylephrine or propranolol therapy (Di Girolamo 1998).

There are very few bibiographical references and it is marketed in few countries.

Alternatives

We do not have alternatives for Etilefrine Hydrochloride.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Etilefrine Hydrochloride is also known as


Etilefrine Hydrochloride in other languages or writings:

Group

Etilefrine Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Etilefrine Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 12 %
Molecular weight 218 daltons
Protein Binding 23 %
pKa 9,1 -
Tmax 0,33 hours
T1/2 2 hours

References

  1. Sanofi. Etilefrina. Ficha técnica. 2020 Full text (in our servers)
  2. Sanofi. Etilefrine. Drug Summary. 2005 Full text (in our servers)
  3. Di Girolamo E, Di Iorio C, Sabatini P, Leonzio L, Barsotti A. [Evaluation of the effects of diverse therapeutic treatments versus no treatment of patients with neurocardiogenic syncope]. Cardiologia. 1998 Aug;43(8):833-7. Italian. Abstract

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