Last update: June 11, 2018

Esomeprazole

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

S-Enantiomer of Omeprazole with which shares similar characteristics.

Due to a high serum-protein-binding capacity (AEMPS 2012), Omeprazole is excreted into breast milk in non-significant amount (Marshall 1998) without side-effects among breastfed infants from treated mothers (Nava 2006).

Since it's neutralized by the acid pH of stomach, capsules with enteric coated granules are used. Because of this, it is thought that the small quantity of Omeprazole that may reach the breast milk would be neutralized by infant's stomach. In addition, absorption is greatly decreased by the presence of food.

Esomeprazole has been used for treatment of newborn and premature infants (Omari 2009).

Hyperprolactinemia and galactorrhea have been reported by the use of Omeprazole (Pipaliya 2016, Jabbar 2010).

Alternatives

We do not have alternatives for Esomeprazole since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Esomeprazole is also known as


Esomeprazole in other languages or writings:

Tradenames

Main tradenames from several countries containing Esomeprazole in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 64 - 89 %
Molecular weight 767 daltons
Protein Binding 97 %
VD 0,23 l/Kg
Tmax 1,5 hours
T1/2 1 - 1,4 hours

References

  1. Pipaliya N, Solanke D, Rathi C, Patel R, Ingle M, Sawant P. Esomeprazole induced galactorrhea: a novel side effect. Clin J Gastroenterol. 2016 Abstract
  2. Esomeprazol Ficha técnica 2012 Full text (in our servers)
  3. Jabbar A, Khan R, Farrukh SN. Hyperprolactinaemia induced by proton pump inhibitor. J Pak Med Assoc. 2010 Abstract
  4. Omari T, Lundborg P, Sandström M, Bondarov P, Fjellman M, Haslam R, Davidson G. Pharmacodynamics and systemic exposure of esomeprazole in preterm infants and term neonates with gastroesophageal reflux disease. J Pediatr. 2009 Abstract
  5. Nava-Ocampo AA, Velázquez-Armenta EY, Han JY, Koren G. Use of proton pump inhibitors during pregnancy and breastfeeding. Can Fam Physician. 2006 Abstract Full text (link to original source) Full text (in our servers)
  6. Andersson T, Hassan-Alin M, Hasselgren G, Röhss K, Weidolf L. Pharmacokinetic studies with esomeprazole, the (S)-isomer of omeprazole. Clin Pharmacokinet. 2001 Abstract
  7. Marshall JK, Thompson AB, Armstrong D. Omeprazole for refractory gastroesophageal reflux disease during pregnancy and lactation. Can J Gastroenterol. 1998 Abstract
  8. Cederberg C, Andersson T, Skånberg I. Omeprazole: pharmacokinetics and metabolism in man. Scand J Gastroenterol Suppl. 1989 Abstract

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