Last update: Feb. 22, 2016

Dipivefrine Hydrochloride

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Ester and prodrug of epinephrine which is used as topical eye drops for treatment of glaucoma.

Because the small dose used and poor plasma absorption of most ophthalmic preparations it is unlikely the passage of significant amount into breast milk.
Absorption can be minimized by closing the eye after instillation and applying pressure for one minute with your finger on the tear duct at the inner corner of the eye.

A low oral bioavailability may hinder its passage to the infant's plasma from ingested milk.

Alternatives

We do not have alternatives for Dipivefrine Hydrochloride since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Dipivefrine Hydrochloride in other languages or writings:

Group

Dipivefrine Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Dipivefrine Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Bioavailability Baja - Low %
Molecular weight 388 daltons
Tmax 1 hours

References

  1. Ness T, Paulus W. [Ophthalmic agents during pregnancy and breastfeeding]. Ophthalmologe. 2012 Abstract
  2. Bozhich M, Khentova-Senchanich P, Kontich J, Markovich V, Mar'ianovich I. [Glaucoma treatment during pregnancy and lactation]. Vestn Oftalmol. 2011 Abstract
  3. Coppens G, Stalmans I, Zeyen T. Glaucoma medication during pregnancy and nursing. Bull Soc Belge Ophtalmol. 2010 Abstract
  4. Labetoulle M, Gendron G, Offret H. [Eyedrops in children and pregnant or breast-feeding woman: why so many difficulties?]. J Fr Ophtalmol. 2009 Abstract
  5. Madadi P, Koren G, Freeman DJ, Oertel R, Campbell RJ, Trope GE. Timolol concentrations in breast milk of a woman treated for glaucoma: calculation of neonatal exposure. J Glaucoma. 2008 Abstract
  6. Johnson SM, Martinez M, Freedman S. Management of glaucoma in pregnancy and lactation. Surv Ophthalmol. 2001 Abstract
  7. Mekki QA, Warrington SJ, Turner P. Bromocriptine eyedrops lower intraocular pressure without affecting prolactin levels. Lancet. 1984 Abstract

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