Last update: July 15, 2017

Dimetindene Maleate (Topical use)

Very Low Risk for breastfeeding

Safe. Compatible.
Not risky for breastfeeding or infant.

First generation antihistamine, alkylamine, with sedative and antimuscarinic effect.
It is used in the form of gel or cream for itchy skin relief.

At latest update no published data on excretion into breast milk was found.

Because a low dermal absorption and high plasma protein binding capacity, the passage of a significant amount into breast milk is unlikely.

Do not apply on the chest to prevent ingestion by the infant; otherwise, apply it after having nursed the infant and rinse it thoroughly with water before the next feeding.
Avoid applying creams, gels and other local application product containing paraffin to the nipple (mineral oil) for the infant not absorbed.

The systemic use (oral, nasal or intravenous inhalation) during breastfeeding
is considered to risky. See Dimethindene maleate (systemic use)

See below the information of this related product:


We do not have alternatives for Dimetindene Maleate (Topical use) since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Dimetindene Maleate (Topical use) is also known as

Dimetindene Maleate (Topical use) in other languages or writings:


Dimetindene Maleate (Topical use) belongs to this group or family:


Main tradenames from several countries containing Dimetindene Maleate (Topical use) in its composition:


Variable Value Unit
Oral Bioavail. (dermal) 10 %
Molecular weight 409 daltons
Protein Binding 90 %
T1/2 6 hours


  1. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008 Abstract
  2. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003 Abstract
  3. AEMPS. Dimetindeno emulsión Ficha técnica. 2000 Full text (in our servers)
  4. Radler S, Blaschke G. Transdermal absorption of dimethindene in man. Arch Pharm (Weinheim). 1995 Abstract
  5. Arnera V, Wermeille M, Wellman M, Llull JB, Althaus MA, Balant LP. Pharmacokinetics of dimetindene after intravenous and oral administration to healthy volunteers. Arzneimittelforschung. 1990 Abstract

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