Last update: Aug. 30, 2018

Дифеноксилата Гидрохлорид

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

An opioid, synthetic derivative of pethidine with little or no analgesic effect. It acts by decreasing intestinal motility and with it the frequency and fluidity of bowel movements.
Used orally every 6 hours for the symptomatic treatment of acute diarrhea.

Since the last update we did not found published data on its excretion in breastmilk.

Although the manufacturer warns that its active metabolite could be excreted in breastmilk (Pfizer 2017), several expert authors believe that excretion in breastmilk is minimal (Hale 2017 p289, Chen 2010).

In order to prevent its abuse it is often associated with atropine, which could affect breastfed children (Gattuso 1994). However, the American Academy of Pediatrics classifies atropine as compatible with breastfeeding (AAP 2001).

Its indiscriminate use in gastroenteritis is not justifiable. Most gastroenteritis does not require medication: good hydration and maintaining a normal diet is sufficient.

Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Дифеноксилата Гидрохлорид is Diphenoxylate Hydrochloride in Cyrillic.

Is written in other languages:

Tradenames

Main tradenames from several countries containing Дифеноксилата Гидрохлорид in its composition:

  • Colestase™. Contains other elements than Дифеноксилата Гидрохлорид in its composition
  • Dymotil™. Contains other elements than Дифеноксилата Гидрохлорид in its composition
  • Lofenoxal™. Contains other elements than Дифеноксилата Гидрохлорид in its composition
  • Logen™. Contains other elements than Дифеноксилата Гидрохлорид in its composition
  • Lomotil™. Contains other elements than Дифеноксилата Гидрохлорид in its composition
  • Retardin™. Contains other elements than Дифеноксилата Гидрохлорид in its composition

Pharmacokinetics

Variable Value Unit
Bioavailability 90 %
Molecular weight 489 daltons
Protein Binding 90 (74 - 95) %
VD 3,8 l/Kg
pKa 8,5 -
Tmax 2 hours
T1/2 12 - 14 hours

References

  1. Pfizer. Diphenoxylate. Drug Summary. 2017 Full text (in our servers)
  2. Hale TW, Rowe HE. Medications & Mothers' Milk. A Manual of Lactation Pharmacology. Springer Publishing Company. 2017
  3. Chen LH, Zeind C, Mackell S, LaPointe T, Mutsch M, Wilson ME. Breastfeeding travelers: precautions and recommendations. J Travel Med. 2010 Jan-Feb;17(1):32-47. Abstract Full text (link to original source) Full text (in our servers)
  4. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  5. Gattuso JM, Kamm MA. Adverse effects of drugs used in the management of constipation and diarrhoea. Drug Saf. 1994 Abstract

Total visits

267

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write to us at elactancia.org@gmail.com

e-lactancia is a resource recommended by La Liga de la Leche de Euskadi

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM