Last update: July 24, 2014

Demeclocycline

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

Although it is secreted into breast milk it has not been detected in infant’s blood because it forms unabsorbable chelate compounds with milk calcium. It is not recommended a long-term use (more than 3-4 weeks) since damage on bone growth plates, teeth discoloration, or alteration of intestinal flora may occur.

Be aware of the possibility of false negative results of bacterial cultures when the mother is on antibiotics.

Withdrawn from the market in Spain.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Demeclocycline is also known as


Group

Demeclocycline belongs to this group or family:

Tradenames

Main tradenames from several countries containing Demeclocycline in its composition:

Pharmacokinetics

Variable Value Unit
Bioavailability 66 %
Molecular weight 501 daltons
Protein Binding 70 %
Tmax 4 hours
T1/2 12 hours
M/P ratio 0,7 -
Theoretical Dose 0,15 mg/Kg/d
Relative Dose 1,5 %

References

  1. Chin KG, McPherson CE 3rd, Hoffman M, Kuchta A, Mactal-Haaf C. Use of anti-infective agents during lactation: Part 2--Aminoglycosides, macrolides, quinolones, sulfonamides, trimethoprim, tetracyclines, chloramphenicol, clindamycin, and metronidazole. J Hum Lact. 2001 Feb;17(1):54-65. Abstract

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