Last update: Aug. 30, 2018

达那唑

Very High Risk for breastfeeding


Very unsafe. Contraindicated.
Use of an alternative or cessation of breastfeeding.

A synthetic steroid with antigonadotropic and antiestrogenic activity due to the suppression of the pituitary gland’s gonadotropic hormone and with androgenic effects (Sanofi 2017, AEMPS 2017).
Used to treat endometriosis, fibrocystic breast disease, hereditary angioedema, mastalgia, premenstrual syndrome and menorrhagia.
Administration orally twice a day.

Since the last update we have not found published data on its excretion in breastmilk or its effect on breastfed infants (Briggs 2017).

In the absence of data regarding protein binding and the volume of distribution, the known pharmacokinetic data (low molecular weight, high pKa and prolonged half-life) make it likely that it would transfer to milk in amounts which could be significant.

Due to its possible androgenic effect on the infant and inhibition of prolactin, it should be avoided during breastfeeding (Hale 2019 p193, Sanofi 2017, AEMPS 2017).

Alternatives

We do not have alternatives for 达那唑.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

达那唑 is Danazol in Chinese.

Is written in other languages:

Tradenames

Main tradenames from several countries containing 达那唑 in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 338 daltons
pKa 13,1 -
Tmax 2 hours
T1/2 4,5 - 29 hours

References

  1. Hale TW. Hale's Medications & Mothers' Milk. Springer Publishing Company. 2019
  2. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. 11th edition (acces on line) 2017
  3. AEMPS. Danazol. Ficha técnica. 2017 Full text (in our servers)
  4. Sanofi. Danazol. Drug Summary. 2017 Full text (in our servers)

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