Last update: June 11, 2018

Colesevelam Hydrochloride

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

Resina-polímero que disminuye la absorción intestinal de ácidos biliares y colesterol.
Administración oral una o dos veces al día.

A fecha de última actualización no encontramos datos publicados en relación con la lactancia.

La absorción intestinal del fármaco es nula (EMA 2017, Heller 2002, Steinmetz 2002), por lo que ni puede pasar a leche materna, ni pasaría a plasma del lactante a partir de la leche materna ingerida.

Es poco probable que pueda alterar la composición lipídica de la leche. Los lactantes necesitan ingerir cantidades elevadas de colesterol, ya que es fundamental para el correcto desarrollo del sistema nervioso, de las membranas celulares y es precursor de varias hormonas y vitaminas.

Parece interferir menos que otras resinas hipolipemiantes con la absorción de vitaminas liposolubles (A, D, E, K).

Diversos expertos consideran probablemente seguro el uso de esta medicación durante la lactancia (Hale 2017 p232, Briggs 2015).

Conviene seguir una dieta hipolipemiante.
Suspender el tratamiento farmacológico de la hipercolesterolemia durante el periodo de lactancia no es probable que altere significativamente el resultado a largo plazo de la enfermedad.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Group

Colesevelam Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Colesevelam Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0,05 %

References

  1. Hale TW, Rowe HE. Medications & Mothers' Milk. A Manual of Lactation Pharmacology. Springer Publishing Company. 2017
  2. EMA. Colesevelam. Drug Summary. 2017 Full text (in our servers)
  3. EMA. Colesevelam. Ficha técnica. 2017 Full text (in our servers)
  4. Lawrence RA, Lawrence RM. Breastfeeding. A guide for the medical profession. Eighth Edition. Philadelphia: Elsevier; 2016
  5. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  6. Heller DP, Burke SK, Davidson DM, Donovan JM. Absorption of colesevelam hydrochloride in healthy volunteers. Ann Pharmacother. 2002 Abstract
  7. Steinmetz KL. Colesevelam hydrochloride. Am J Health Syst Pharm. 2002 Abstract

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