Last update: Feb. 19, 2019

Choriogonadotropin Alfa

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

It is the synthetic form of the natural human chorionic gonadotropin (hCG) hormone, produced by recombinant DNA technology.
Administration by subcutaneous injection.
Indicated to stimulate ovulation in assisted reproduction techniques.

Since the last update we have not found published data on its excretion in breastmilk.

Its high molecular weight makes it very unlikely it will transfer into milk in significant quantities.

Due to its protein nature it is inactivated in the gastrointestinal tract, not being absorbed, so its oral bioavailability is practically nil, except in premature babies and the immediate neonatal period when there may be greater intestinal permeability.

May cause increased prolactin and galactorrhea (Mendes 2001).

No adverse effects have been recorded in infants.

In infertility treatments, the possible theoretical anovulatory effect of frequent on demand breastfeeding must be taken into account.


See below the information of these related products:

Alternatives

We do not have alternatives for Choriogonadotropin Alfa.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Choriogonadotropin Alfa is also known as


Choriogonadotropin Alfa in other languages or writings:

Group

Choriogonadotropin Alfa belongs to this group or family:

Tradenames

Main tradenames from several countries containing Choriogonadotropin Alfa in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 25.720 daltons
VD 0,9 l/Kg
T1/2 29 ± 6 hours

References

  1. EMA. Coriogonadotropina alfa (Ovitrelle). Ficha técnica. 2017 Full text (in our servers)
  2. EMA. Choriogonadotropin alfa (Ovitrelle). Drug Summary 2017 Full text (in our servers)
  3. Mendes MC, Ferriani RA, Sala MM, Moura MD, Carrara HH, de Sá MF. Effect of transitory hyperprolactinemia on in vitro fertilization of human oocytes. J Reprod Med. 2001 Abstract

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