Last update: Oct. 11, 2017

Chlorotrianisene

High Risk for breastfeeding


Poorly safe. Evaluate carefully.
Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives).
Read the Comment.

A non-steroidal synthetic estrogen similar to diethylstilbestrol.

Since the last update we have not found published data about its excretion in breast milk.

It has been used orally to inhibit postpartum lactation (Oladapo 2012, Niebyl 1979, Yuen 1977, Utian 1975) and to treat menopausal symptoms, female hypogonadism and prostate carcinoma.

Very long acting due to accumulation in adipose tissue.

Not currently commercially available.


See below the information of this related product:

Alternatives

We do not have alternatives for Chlorotrianisene.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Chlorotrianisene is also known as


Chlorotrianisene in other languages or writings:

Group

Chlorotrianisene belongs to this group or family:

Tradenames

Main tradenames from several countries containing Chlorotrianisene in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 381 daltons
Protein Binding 50 - 80 %

References

  1. Oladapo OT, Fawole B. Treatments for suppression of lactation. Cochrane Database Syst Rev. 2012 Abstract
  2. Niebyl JR, Bell WR, Schaaf ME, Blake DA, Dubin NH, King TM. The effect of chlorotrianisene as postpartum lactation suppression on blood coagulation factors. Am J Obstet Gynecol. 1979 Abstract
  3. Yuen BH, Pendleton HJ, Blair S. Efficacy of bromocriptine and chlorotrianisene in preventing postpartum lactation. Can Med Assoc J. 1977 Abstract
  4. Utian WH, Begg G, Vinik AI, Paul M, Shuman L. Effect of bromocriptine and chlorotrianisene on inhibition of lactation and serum prolactin. A comparative double-blind study. Br J Obstet Gynaecol. 1975 Abstract

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