Last update: Oct. 15, 2016

Cefprozil

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Second-generation cephalosporin for oral administration.

Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant (Shyu 1992).

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding

Alternatives

We do not have alternatives for Cefprozil since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Cefprozil in other languages or writings:

Group

Cefprozil belongs to this group or family:

Tradenames

Main tradenames from several countries containing Cefprozil in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 95 %
Molecular weight 407 daltons
Protein Binding 35 - 45 %
VD 0,23 l/Kg
Tmax 1 - 2 hours
T1/2 1 - 1,4 hours
Theoretical Dose 0,1 - 0,2 mg/Kg/d
Relative Dose 0,6 - 3,3 %
Relat.Ped.Dose 1,7 - 3,3 %

References

  1. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  2. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  3. Shyu WC, Shah VR, Campbell DA, Venitz J, Jaganathan V, Pittman KA, Wilber RB, Barbhaiya RH. Excretion of cefprozil into human breast milk. Antimicrob Agents Chemother. 1992 Abstract Full text (link to original source) Full text (in our servers)

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