Last update: Oct. 15, 2016

Cefoperazone Sodium

Very Low Risk for breastfeeding

Safe. Compatible.
Minimal risk for breastfeeding and infant.

Third-generation cephalosporin for injection or parenteral administration.

Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant (Takase 1980, Matsuda 1984 y 85).

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.


We do not have alternatives for Cefoperazone Sodium since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Cefoperazone Sodium in other languages or writings:


Cefoperazone Sodium belongs to this group or family:


Main tradenames from several countries containing Cefoperazone Sodium in its composition:


Variable Value Unit
Oral Bioavail. Baja - Poor %
Molecular weight 668 daltons
Protein Binding 82 - 93 %
VD 0,19 l/Kg
Tmax 1,1 - 2,5 hours
T1/2 2 hours
M/P ratio 0,12 -
Theoretical Dose 0,015 - 0,045 mg/Kg/d
Relative Dose 0,09 - 0,27 %
Relat.Ped.Dose 0,06 - 0,1 %


  1. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  2. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  3. Matsuda S, Kashiwagura T, Hirayama H. [Passage into the human milk and clinical evaluation of sulbactam/cefoperazone]. Jpn J Antibiot. 1985 Abstract
  4. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984;5(2):57-60. Abstract
  5. Takase Z, Shirafuji H, Uchida M. Fundamental and clinical studies of cefoperazone (T-1551) in the field of obstetrics and gynecology. Chemotherapy (Tokyo). 1980;28 (Suppl 6):825-36. 1980

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