Last update: July 31, 2016

Cefixime

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

This is a third generation Cephalosporin.

At latest update relevant data on excretion into breast milk were not found. On other type of Cephalosporin for which there is available information, excretion into breast milk is therapeutically non-significant.

Cephalosporin is commonly used in Pediatrics, even in neonates, with a good tolerance, which may be a reason to think that the presence of small amounts in the milk would not represent any harm to the child.

Be aware of the possibility of false negative results of bacterial cultures done to infants when the mother is on antibiotics, together with a higher risk of diarrheal disease due to imbalance of intestinal flora.

Alternatives

We do not have alternatives for Cefixime since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Cefixime in other languages or writings:

Pharmacokinetics

Variable Value Unit
Bioavailability 30 - 50 %
Molecular weight 508 daltons
Protein Binding 65 %
VD 0,1 l/Kg
Tmax 2 - 6 hours
T1/2 3 - 4 hours

References

  1. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  2. Bar-Oz B, Bulkowstein M, Benyamini L, Greenberg R, Soriano I, Zimmerman D, Bortnik O, Berkovitch M. Use of antibiotic and analgesic drugs during lactation. Drug Saf. 2003 Abstract
  3. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  4. Barré J. [Pharmacokinetic properties of cefixime]. Presse Med. 1989 Abstract
  5. Faulkner RD, Fernandez P, Lawrence G, Sia LL, Falkowski AJ, Weiss AI, Yacobi A, Silber BM. Absolute bioavailability of cefixime in man. J Clin Pharmacol. 1988 Abstract
  6. Brittain DC, Scully BE, Hirose T, Neu HC. The pharmacokinetic and bactericidal characteristics of oral cefixime. Clin Pharmacol Ther. 1985 Abstract

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