Last update: Sept. 19, 2016

Cefepime Hydrochloride

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Fourth-generation cephalosporin for injection or parenteral administration.

Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant (Sanders 1993, Bristol-Myers Squibb 2009).

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

Alternatives

We do not have alternatives for Cefepime Hydrochloride since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Cefepime Hydrochloride in other languages or writings:

Group

Cefepime Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Cefepime Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Bioavailability Baja - Low %
Molecular weight 572 daltons
Protein Binding 20 %
VD 0,3 l/Kg
Tmax 0,5 - 1,5 hours
T1/2 2 ± 0.3 hours
M/P ratio 0,8 -
Theoretical Dose 0,075 mg/Kg/d
Relative Dose 0,11 - 0,23 %
Relat.Ped.Dose 0,075 - 0,125 %

References

  1. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  2. Bristol-Myers Squibb. Cefepime. Drug Summary. 2009 Full text (in our servers)
  3. Bar-Oz B, Bulkowstein M, Benyamini L, Greenberg R, Soriano I, Zimmerman D, Bortnik O, Berkovitch M. Use of antibiotic and analgesic drugs during lactation. Drug Saf. 2003 Abstract
  4. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  5. Okamoto MP, Nakahiro RK, Chin A, Bedikian A. Cefepime clinical pharmacokinetics. Clin Pharmacokinet. 1993 Abstract
  6. Sanders CC. Cefepime: the next generation? Clin Infect Dis. 1993 Abstract
  7. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract

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