Last update: Oct. 15, 2016

Cefditoren Pivoxil

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Third generation cephalosporins for oral administration.

At latest update no published data on excretion into breast milk were found.

Most cephalosporins are excreted into milk in insignificant amounts from a therapeutic point of view without reported complications in infants.
Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Pharmacokinetic data (moderately high molecular weight, high protein binding capacity and short half-life span) make unlikely the milk passage of significant amounts into breast milk.
Their low oral bioavailability hinders the passage from ingested milk to the infant’s plasma except in preterm babies and immediate neonatal period, when they may exhibit an increased intestinal permeability.

Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

Alternatives

We do not have alternatives for Cefditoren Pivoxil since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Cefditoren Pivoxil in other languages or writings:

Group

Cefditoren Pivoxil belongs to this group or family:

Tradenames

Main tradenames from several countries containing Cefditoren Pivoxil in its composition:

Pharmacokinetics

Variable Value Unit
Bioavailability 14 %
Molecular weight 621 daltons
Protein Binding 88 %
VD 9,3 l/Kg
Tmax 1,5 - 3 hours
T1/2 1,6 hours

References

  1. Bar-Oz B, Bulkowstein M, Benyamini L, Greenberg R, Soriano I, Zimmerman D, Bortnik O, Berkovitch M. Use of antibiotic and analgesic drugs during lactation. Drug Saf. 2003 Abstract
  2. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  3. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  4. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984 Abstract
  5. Kafetzis DA, Siafas CA, Georgakopoulos PA, Papadatos CJ. Passage of cephalosporins and amoxicillin into the breast milk. Acta Paediatr Scand. 1981 Abstract

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