Last update: Sept. 19, 2016

C26H37NO3

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

Antimuscarinic agent with atropine-like action. It is metabolized in Tolterodine

At latest update no published data on excretion into breast milk were found.

Until more published data on this drug in relation to breastfeeding is available, a known safer alternative as Tolterodine should be preferred with more favorable pharmacokinetics characteristics for lactation (e.g. high protein-binding capacity, faster elimination and lower oral bioavailability), particularly during the neonatal period and prematurity case.

Take as smallest dose as possible and avoid long-term use since anticholinergics can reduce milk production.

Monitoring anticholinergic symptoms in infants (dry mouth, constipation ..) is warranted.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

C26H37NO3 is Fesoterodine in Molecular formula.

Is written in other languages:

C26H37NO3 is also known as

Tradenames

Main tradenames from several countries containing C26H37NO3 in its composition:

Pharmacokinetics

Variable Value Unit
Bioavailability 52 %
Molecular weight 412 daltons
Protein Binding 50 %
VD 2,4 l/Kg
Tmax 5 hours
T1/2 7 hours

References

  1. EMA. Fesoterodina. Ficha técnica. 2014 Full text (in our servers)
  2. EMA. Fesoterodine. Drug Summary. 2014 Full text (in our servers)
  3. Bizzarro A, Iannucci F, Tolino A, Soricelli A, Guarino G, Verdoliva A. Inhibiting effect of atropine on prolactin blood levels after stimulation with TRH. Clin Exp Obstet Gynecol. 1980 Abstract

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