Last update: Jan. 2, 2021

Brimonidine Tartrate

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

Simpaticomimético agonista de los receptores alfa-2 adrenérgicos.
Indicado en el tratamiento de la hipertensión ocular, del glaucoma y del eritema facial de la rosácea
Administración tópica en forma de colirio, una gota cada 12 horas o en crema facial una aplicación cada 24 horas.

A fecha de última actualización no encontramos datos publicados sobre su excreción en leche materna.

Las concentraciones plasmáticas son bajas con el tratamiento oftálmico y mucho más bajas tras la administración cutánea facial (Allergan 2020, EMA 2019 y 2018), lo que hace poco probable el paso a leche materna en concentración significativa.

Aunque algunos autores lo desaconsejan durante la lactancia por el posible paso a leche materna (Belkin 2020, Blumen 2020, Salim 2014, Coleman 2005), lo cierto es que al menos dos lactantes de madres tratadas con brimonidina (uno de ellos, durante 6 meses) no presentaros ningún problema clínico (Madadi 2008, Johnson 2001).

Conviene minimizar la absorción sistémica presionando con el dedo el conducto lacrimal (canto interno del ojo) durante 1 a 5 minutos y administrando la dosis inmediatamente después de una toma de pecho (Belkin 2020, Méndez 2012).

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

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Other names

Brimonidine Tartrate in other languages or writings:

Groups

Brimonidine Tartrate belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Brimonidine Tartrate in its composition:

List of 13 tradenames

Pharmacokinetics

Variable Value Unit
Molecular weight 442 daltons
Protein Binding 29 %
pKa 8,3 -
Tmax 0,5 -2 hours
T1/2 2 - 3 hours

References

  1. Blumen-Ohana E, Sellem E. Grossesse & glaucome : recommandations SFO—SFG. [Pregnancy & glaucoma: SFO-SFG recommendations]. J Fr Ophtalmol. 2020 Jan;43(1):63-66. Abstract
  2. Belkin A, Chen T, DeOliveria AR, Johnson SM, Ramulu PY, Buys YM; American Glaucoma Society and the Canadian Glaucoma Society.. A Practical Guide to the Pregnant and Breastfeeding Patient with Glaucoma. Ophthalmol Glaucoma. 2020 Mar - Apr;3(2):79-89. Abstract
  3. Allergan. Brimonidina (oftálmica). Ficha técnica. 2020 Full text (in our servers)
  4. EMA Brimonidine (ophtalmic). Drug Summary. 2019 Full text (in our servers)
  5. EMA. Brimonidina (dermatológica). Ficha técnica. 2018 Full text (in our servers)
  6. EMA. Brimonidine (dermatological). Drug Summary. 2018 Full text (in our servers)
  7. Salim S. Glaucoma in pregnancy. Curr Opin Ophthalmol. 2014 Mar;25(2):93-7. Abstract
  8. Méndez-Hernández C. [Use of glaucoma medications during pregnancy and breastfeeding]. Arch Soc Esp Oftalmol. 2012 Dec;87(12):389-91. Abstract
  9. Madadi P, Koren G, Freeman DJ, Oertel R, Campbell RJ, Trope GE. Timolol concentrations in breast milk of a woman treated for glaucoma: calculation of neonatal exposure. J Glaucoma. 2008 Jun-Jul;17(4):329-31. Abstract
  10. Coleman AL, Mosaed S, Kamal D. Medical therapy in pregnancy. J Glaucoma. 2005 Oct;14(5):414-6. No abstract available. Abstract
  11. Johnson SM, Martinez M, Freedman S. Management of glaucoma in pregnancy and lactation. Surv Ophthalmol. 2001 Mar-Apr;45(5):449-54. Abstract

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