Last update: June 9, 2018

Boric Acid

High Risk for breastfeeding


Poorly safe. Evaluate carefully.
Use safer alternative or interrupt breastfeeding 3 to 7 T½.
Read the Comment.

A chemical product used medically as a topical antiseptic (bacteria and fungi). It is also used as a disinfectant, insecticide and has other industrial uses. Given its toxic nature, its use as a food preservative has been abandoned. It is still used in the treatment of vaginal candidiasis when resistant to other treatment (Iavazzo 2011).

Since the last update we have not found published data on its excretion in breastmilk.

Absorption through intact skin is negligible (0.23%) (U.S. 2010, Wester 1998). Vaginal absorption is 6% (Prutting 1998).
Virtually everything absorbed via inhalation is eliminated in 24 hours and 96 hours if the absorption was through the digestive tract.

These periods of 24 and 96 hours can respectively be prudent periods of suspending breastfeeding in case the breastfeeding mother has been seriously intoxicated by inhalation or oral administration.

Alternatives

We do not have alternatives for Boric Acid.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Boric Acid is also known as


Boric Acid in other languages or writings:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 81 - 92 (oral) %
Molecular weight 62 daltons
VD 0,25 - 0,46 l/Kg
T1/2 13,4 (4 - 28) hours

References

  1. Iavazzo C, Gkegkes ID, Zarkada IM, Falagas ME. Boric acid for recurrent vulvovaginal candidiasis: the clinical evidence. J Womens Health (Larchmt). 2011 Abstract
  2. U.S. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Boron. 2010 Full text (link to original source) Full text (in our servers)
  3. Prutting SM, Cerveny JD. Boric acid vaginal suppositories: a brief review. Infect Dis Obstet Gynecol. 1998 Abstract Full text (link to original source) Full text (in our servers)
  4. Wester RC, Hui X, Maibach HI, Bell K, Schell MJ, Northington DJ, Strong P, Culver BD. In vivo percutaneous absorption of boron as boric acid, borax, and disodium octaborate tetrahydrate in humans: a summary. Biol Trace Elem Res. 1998 Abstract
  5. Teshima D, Morishita K, Ueda Y, Futagami K, Higuchi S, Komoda T, Nanishi F, Taniyama T, Yoshitake J, Aoyama T. Clinical management of boric acid ingestion: pharmacokinetic assessment of efficacy of hemodialysis for treatment of acute boric acid poisoning. J Pharmacobiodyn. 1992 Abstract
  6. Jansen JA, Andersen J, Schou JS. Boric acid single dose pharmacokinetics after intravenous administration to man. Arch Toxicol. 1984 Abstract

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