Last update: Jan. 29, 2017

Bisacodyl

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

A laxative which acts as stimulant in the intestine.

A low oral bioavailability due to minimal intestinal absorption that renders the plasma levels being very low would explain the non passage to breast milk observed (undetectable levels: Friedrich 2011).

On prevention or treating constipation, it is essential a balanced and rich-in-fiber diet along with a lot of fluids and physical exercise.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Bisacodyl in other languages or writings:

Group

Bisacodyl belongs to this group or family:

Tradenames

Main tradenames from several countries containing Bisacodyl in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. < 5 %
Molecular weight 361 daltons
Tmax 4 - 10 hours
T1/2 16,5 hours
Theoretical Dose 0 mg/Kg/d
Relative Dose 0 %
Relat.Ped.Dose 0 %

References

  1. Gharehbaghi K, Gharehbaghi DR, Wierrani F, Sliutz G. [Treatment of Chronic Functional Constipation during Pregnancy and Lactation]. Z Geburtshilfe Neonatol. 2016 Abstract
  2. Müller-Lissner S. Pharmacokinetic and pharmacodynamic considerations for the current chronic constipation treatments. Expert Opin Drug Metab Toxicol. 2013 Abstract
  3. AEMPS. Bisacodilo. Ficha técnica. 2012 Full text (in our servers)
  4. Friedrich C, Richter E, Trommeshauser D, de Kruif S, van Iersel T, Mandel K, Gessner U. Absence of excretion of the active moiety of bisacodyl and sodium picosulfate into human breast milk: an open-label, parallel-group, multiple-dose study in healthy lactating women. Drug Metab Pharmacokinet. 2011 Abstract Full text (link to original source) Full text (in our servers)
  5. Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006 Jul;131(1):283-311. Review. Abstract Full text (link to original source) Full text (in our servers)
  6. Müller-Lissner S. [Side effects of laxatives]. Z Gastroenterol. 1992 Abstract
  7. Anderson PO. Drug use during breast-feeding. Clin Pharm. 1991 Abstract
  8. Vorherr H. Drug excretion in breast milk. Postgrad Med. 1974 Oct;56(4):97-104. Review. No abstract available. Abstract

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