Last update: Aug. 22, 2019


Very Low Risk for breastfeeding

Safe. Compatible.
Minimal risk for breastfeeding and infant.

Local anesthetic indicated for the relief of cutaneous, vaginal, rectal, otic, dental and oral mucosa pain and itching.
Topical application.

Since the last update we have not found published data on its excretion in breastmilk.

Topical anesthetics (dermatological, otological and stomatological preparations) when applied well have virtually no systemic absorption through intact or mucosal skin, so that levels in plasma and breastmilk are zero or insignificant and do not pose any danger to the infant (Hale 2019 p, PDR 2018, AEMPS 2018, Briggs 2017, AEMPS 2008, Nice 2000).

Benzocaine can produce methemoglobinemia and systemic toxicity if absorbed (PCR 2018, AEMPS 2018, Hoffman 2015, Lepe 2015, Bittmann 2011, Chung 2010, Bouziri 2010, Bong 2009).

Do not apply to the breast or, if necessary, apply after a feed and clean thoroughly with water before the next one.
Never apply to the nipple.


Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Benzocaïne is Benzocaine in French.

Is written in other languages:

Benzocaïne is also known as


Main tradenames from several countries containing Benzocaïne in its composition:


Variable Value Unit
Oral Bioavail. < 10 %
Molecular weight 165 daltons


  1. AEMPS. Angileptol. Ficha técnica. 2019 Full text (in our servers)
  2. AEMPS. Benzocaína. Ficha técnica. 2018 Full text (in our servers)
  3. Benzocaine (Anbesol). Drug Summary. 2018 Full text (link to original source) Full text (in our servers)
  4. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  5. Lepe-Zúñiga JL, Aguilar-Gómez LE, Godínez-Téllez NC. [Association of benzocaine and paracetamol with neonatal-acquired methemoglobinemia]. Bol Med Hosp Infant Mex. 2015 Abstract
  6. Hoffman C, Abubakar H, Kalikiri P, Green M. Nosocomial Methemoglobinemia Resulting from Self-Administration of Benzocaine Spray. Case Rep Anesthesiol. 2015 Abstract
  7. Bittmann S, Krüger C. Benzocaine-induced methaemoglobinaemia: a case study. Br J Nurs. 2011 Abstract
  8. Chung NY, Batra R, Itzkevitch M, Boruchov D, Baldauf M. Severe methemoglobinemia linked to gel-type topical benzocaine use: a case report. J Emerg Med. 2010 Abstract
  9. Bouziri A, Khaldi A, Menif K, Ben Jaballah N. Unusual cause of severe toxic methemoglobinemia in an infant: a case report. Int J Emerg Med. 2010 Abstract Full text (link to original source) Full text (in our servers)
  10. Bong CL, Hilliard J, Seefelder C. Severe methemoglobinemia from topical benzocaine 7.5% (baby orajel) use for teething pain in a toddler. Clin Pediatr (Phila). 2009 Abstract
  11. AEMPS Hemoal (Benzocaína + Efedrina). Ficha técnica. 2008 Full text (in our servers)
  12. Nice FJ, Snyder JL, Kotansky BC. Breastfeeding and over-the-counter medications. J Hum Lact. 2000 Nov;16(4):319-31. Review. Erratum in: J Hum Lact 2001 Feb;17(1):90. Abstract
  13. Hale TW. Hale's Medications & Mothers' Milk. [Internet]. Springer Publishing Company; 1991-. Available from: None

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 from United States of America

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