Last update: July 31, 2018

Benazepril Hydrochloride

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Benazepril and its active metabolite benazeprilat are angiotensin converting enzyme inhibitors (ACEI) used in the treatment of hypertension and heart failure. Oral administration every 12-24 hours.

It is excreted in breastmilk in clinically insignificant amounts (Anderson 2018, AEMPS 2017, FDA 2015, Frank 2004, Shannon 2000, Kaiser 1989) and no problems have been observed in infants whose mothers were taking it (Anderson 2018).

Due to its possible renal toxicity in preterm infants, it is preferable to avoid its use during the neonatal period in case of prematurity. (Serrano 2015).

The protective role of breastfeeding against maternal hypertension has been proven (Park 2018)

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Group

Benazepril Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Benazepril Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 37 %
Molecular weight 461 daltons
Protein Binding 95 %
VD 0,124 l/Kg
pKa 3,53 -
Tmax 1,5 - 4 hours
T1/2 11 hours
M/P ratio 0,01 -
Theoretical Dose 0,0003 mg/Kg/d
Relative Dose 0,09 %

References

  1. Park S, Choi NK. Breastfeeding and Maternal Hypertension. Am J Hypertens. 2018 Abstract
  2. Anderson PO. Treating Hypertension During Breastfeeding. Breastfeed Med. 2018 Abstract
  3. AEMPS. Benazepril. Ficha técnica. 2017 Full text (in our servers)
  4. Malachias MV, Figueiredo CE, Sass N, Antonello IC, Torloni MR, Bortolotto MRF L. 7th Brazilian Guideline of Arterial Hypertension: Chapter 9 - Arterial Hypertension in pregnancy Arq Bras Cardiol. 2016 Abstract Full text (link to original source) Full text (in our servers)
  5. Serrano Aguayo P, García de Quirós Muñoz JM, Bretón Lesmes I, Cózar León MV. Tratamiento de enfermedades endocrinológicas durante la lactancia. [Endocrinologic diseases management during breastfeeding.] Med Clin (Barc). 2015 Abstract
  6. FDA -Validus Pharm. Benazepril. Drug Summary. 2015 Full text (in our servers)
  7. Frank J Nice, Deborah DeEugenio, Traci A DiMino, Ingrid C Freeny, Marissa B Rovnack, and Joseph S Gromelski. Medications and Breast-Feeding: A Guide for Pharmacists, Pharmacy Technicians, and other Healthcare Professionals Part II. Journal of Pharmacy Technology 20 (2), 85-95 2004 Full text (link to original source) Full text (in our servers)
  8. Shannon ME, Malecha SE, Cha AJ. Angiotensin converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) and lactation: an update. J Hum Lact. 2000 Abstract
  9. Kaiser G, Ackerman R, Dieterle W, Fleiss PM. Benazepril and benazeprilat in human plasma and breast milk (abstract). Eur J Clin Pharmacol 1989;36(Suppl): page 303, poster 14.14. 1989

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