Last update: Oct. 15, 2014

Atovaquone

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

Drug used for treatment and prophylaxis of Pneumoystis pneumonia. Also used in combination with Proguanil for treatment of malaria.

On latest update relevant data on breastfeeding was not found.

Pharmacokinetic data indicates that drug excretion into breast milk would not be significant.

It has been approved to treat infants over 5 kg of body weight. May be used in nursing mothers of newborn and babies under 5 kg of body weight since benefit is greater than risk.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Group

Atovaquone belongs to this group or family:

Tradenames

Main tradenames from several countries containing Atovaquone in its composition:

  • Malanil™. Contains other elements than Atovaquone in its composition
  • Malarone™. Contains other elements than Atovaquone in its composition
  • Mepron
  • Promal™. Contains other elements than Atovaquone in its composition
  • Wellvone

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 23 %
Molecular weight 367 daltons
Protein Binding 100 %
Tmax 0 hours
T1/2 48 - 72 hours

References

  1. Arguin PM, Tan KR. Chemoprophylaxis during Pregnancy and Breastfeeding In Chapter 3. Infections diseases related to travel. Malaria. In Centers for Disease Control and Prevention. CDC Health Information for International Travel 2014. 2014 Full text (link to original source) Full text (in our servers)
  2. Chen LH, Zeind C, Mackell S, LaPointe T, Mutsch M, Wilson ME. Breastfeeding travelers: precautions and recommendations. J Travel Med. 2010 Jan-Feb;17(1):32-47. Abstract Full text (link to original source) Full text (in our servers)
  3. [No authors listed] Atovaquone + proguanil: new indication. For children weighing as little as 5 kg; an inconvenient form. A flavoured syrup would be better suited to infants and young children. Prescrire Int. 2009 Abstract
  4. Pérez JL, Carranza C, Mateos F. Antiparasitarios. Revisión de los fármacos útiles en el tratamiento de parasitosis clásicas y emergentes. \ [Antiparasitic drugs. Review of the useful drugs in the treatment of classic and emergent parasitic diseases]. Rev Esp Quimioter. 2009 Jun;22(2):93-105. Review. Spanish. Abstract Full text (link to original source) Full text (in our servers)
  5. Borrmann S, Faucher JF, Bagaphou T, Missinou MA, Binder RK, Pabisch S, Rezbach P, Matsiegui PB, Lell B, Miller G, Kremsner PG. Atovaquone and proguanil versus amodiaquine for the treatment of Plasmodium falciparum malaria in African infants and young children. Clin Infect Dis. 2003 Abstract Full text (in our servers)

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