Last update: June 30, 2015

Acitretin

High Risk for breastfeeding


Poorly safe. Evaluate carefully.
Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives).
Read the Comment.

Synthetic retinoid derivated from vitamin A.

Despite a low amount secreted through the breast milk (<2% of the equivalent maternal dose), some authorities think that product's toxicity justifies to avoid it during breastfeeding.

American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.

Alternatives

We do not have alternatives for Acitretin.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Acitretin is also known as


Acitretin in other languages or writings:

Group

Acitretin belongs to this group or family:

Tradenames

Main tradenames from several countries containing Acitretin in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 70 %
Molecular weight 326 daltons
Protein Binding 90 %
Tmax 6 hours
T1/2 50 -157 hours
M/P ratio 0,18 -
Theoretical Dose 0,006 mg/Kg/d
Relative Dose 1,4 %

References

  1. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014 Mar;70(3):417.e1-10; quiz 427. Abstract
  2. Mervic L. Management of moderate to severe plaque psoriasis in pregnancy and lactation in the era of biologics. Acta Dermatovenerol Alp Pannonica Adriat. 2014 Abstract Full text (link to original source) Full text (in our servers)
  3. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  4. Takizawa S, Fukatsu N, Horii I, Fujii T. Effect of etretinate (aromatic retinoid) treatment during gestation and lactation periods on viability and somatic growth in F1 rats. J Toxicol Sci. 1994 Abstract
  5. Rollman O, Pihl-Lundin I. Acitretin excretion into human breast milk. Acta Derm Venereol. 1990 Abstract
  6. Fleishaker JC, Desai N, McNamara PJ. Possible effect of lactational period on the milk-to-plasma drug concentration ratio in lactating women: results of an in vitro evaluation. J Pharm Sci. 1989 Abstract

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