Last update Sept. 9, 2022

Torsemide

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

It is a loop or high ceiling diuretic with actions similar to those of furosemide. used to treat hypertension and edema associated with heart failure, kidney failure, or liver disease. It causes intense diuresis. Oral administration once daily.

Since the last update we have not found published data on its excretion in breastmilk.

Its pharmacokinetic data (very high percentage of protein binding and wide volume of distribution) make it highly unlikely that significant quantities will pass into breast milk.

Excessive diuresis can reduce milk production. In the past, diuretics and fluid restriction have been used to suppress lactation after calving. (Kall 1977)
Administration of torasemide in the first week after delivery did not decrease the frequency of initial lactation. (Viteri 2018)

Prolonged use of diuretics can inhibit lactation. It is advisable to use the lowest possible dose, especially the first month.

Alternatives

  • Furosemide (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Hydrochlorothiazide ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Torsemide is also known as


Torsemide in other languages or writings:

Group

Torsemide belongs to this group or family:

Tradenames

Main tradenames from several countries containing Torsemide in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 80 %
Molecular weight 348 daltons
Protein Binding 99 %
VD 0.2 l/Kg
pKa 5.92 -
Tmax 1 hours
3.5 hours

References

  1. Viteri OA, Alrais MA, Pedroza C, Hutchinson M, Chauhan SP, Blackwell SC, Sibai BM. Torsemide for Prevention of Persistent Postpartum Hypertension in Women With Preeclampsia: A Randomized Controlled Trial. Obstet Gynecol. 2018 Nov;132(5):1185-1191. Abstract
  2. Kalk WJ, Cominos DC, van der Walt A, van Rooyen AJ. The effect of furosemide on serum prolactin levels in the postpartum period. S Afr Med J. 1977 Abstract

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